Results 261 to 270 of about 24,619,351 (316)

Central data repository

Report from T8.2 updating deliverable D8.2 and describing the setup and maintenance workflow of the central data ...
openaire   +1 more source

BCR::ABL1‐Induced Enhancer Reprogramming Uncovers Hypersensitivity of Ph+B‐ALL Cells to Enhancer‐Targeting Drugs

Advanced Science, EarlyView.
Ng et al. show that the BCR::ABL1 kinase that drives the lymphoid leukemia Ph+B‐ALL modulates enhancer function by coopting signaling‐inducible transcription factors such as MYC, STAT5, and ETV5. BCR::ABL1 thereby promotes the transcriptional program driving and defining this leukemia and renders Ph+B‐ALL cells hypersensitive to enhancer‐inhibiting ...
Han Leng Ng, Trudy Lee Glaser, Jintao Zhu, Mark E. Robinson, Kadriye N. Cosgun, Valeriya Malysheva, Ozgen Deniz, Nicholas T. Crump, Kaiyue Helian, Andrew J. Innes, Richard Burt, Li Sun, George John, Haibin Zhou, Atsunori Kaneshige, Longchuan Bai, Shaomeng Wang, Mikhail Spivakov, Markus Müschen, Niklas Feldhahn   +19 more
wiley   +1 more source

A Perspective on Interactive Theorem Provers in Physics

Advanced Science, EarlyView.
Into an interactive theorem provers (ITPs), one can write mathematical definitions, theorems and proofs, and the correctness of those results is automatically checked. This perspective goes over the best usage of ITPs within physics and motivates the open‐source community run project PhysLean, the aim of which is to be a library for digitalized physics
Joseph Tooby‐Smith
wiley   +1 more source

Multicohort Validation of Gut Microbiome Signatures for Cholangiocarcinoma Diagnosis and Functional Characterization of Bifidobacterium Pseudocatenulatum

Advanced Science, EarlyView.
This study analyzes gut bacteria in cholangiocarcinoma patients, revealing distinct microbial signatures that enable accurate disease detection. Species‐based diagnostic models achieved over 98% accuracy in identifying cholangiocarcinoma and distinguished it from other liver diseases. The research demonstrates that specific beneficial bacteria suppress
Benchen Rao, Jianwen Jiang, Ruiqing Zhang, Dongya Zhang, Chenchen Zhang, Ang Li, Haifeng Lu, Hua Zhang, Lin Zhou, Wenzhi Guo, Peihao Wen, Jianfeng Xue, Jie Pan, Tuerganaili Aji, Zhou Lan, Xianzhi Jiang, Shusen Zheng, Zujiang Yu, Zhigang Ren   +18 more
wiley   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Doehl et al. discovered an adaptive neuroimmune mechanism that induces itch in tick‐exposed guinea pigs, enabling rapid tick removal. This itch‐induced tick removal (IITR) is mediated by an adaptive cellular immune response and is independent of IgG, IgE, or TRPV1.
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Affinity-based protein profiling of MDM2 inhibitor Navtemadlin. [PDF]

Chem Sci
Date A, Wall A, Zhang P, Houghton JW, Lu J, Thomas AM, Kovačič T, Wilson AJ, Tate EW, Barnard A.   +9 more
europepmc   +1 more source

Materials Data Repository

Materials Data Repository
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Global overview of research data repositories: an analysis of re3data registry

Information Discovery and Delivery, 2023
Purpose Data sharing is increasingly being recognized as an essential component of scholarly research and publishing. Sharing data improves results and propels research and discovery forward.
A. Khan, Fayaz Ahmad Loan, Umer Yousuf Parray, Sozia Rashid   +3 more
semanticscholar   +1 more source

Understanding Research Data Repositories as Infrastructures

ASIS&T Annual Meeting, 2021
This study discusses the properties of research data repositories and explores metadata about 2,646 entries in the Registry of Research Data Repositories (re3data.org) to identify the characteristics attributed to infrastructures they exhibit.
Ceilyn Boyd
semanticscholar   +1 more source

A study of Open Access research data repositories developed by BRICS countries

Digital Library Perspectives, 2020
Purpose In the present era, research data is a concern for researchers, as they are trying to find new ways to communicate their research findings and conclusions to other researchers in order to increase visibility and credibility.
Safat Mushtaq Misgar, Ajra Bhat, Zahid Ashraf Wani   +2 more
semanticscholar   +1 more source