Results 111 to 120 of about 4,822,255 (284)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Fair Data Representation for Machine Learning at the Pareto Frontier. [PDF]

J Mach Learn Res, 2023
Xu S, Strohmer T.
europepmc   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Improved contrastive learning model via identification of false-negatives in self-supervised learning

ETRI Journal
Self-supervised learning is a method that learns the data representation through unlabeled data. It is efficient because it learns from large-scale unla-beled data and through continuous research, performance comparable to supervised learning has been ...
Joonsun Auhn, Changsik Cho, Seon-tae Kim
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Variable body and tissue weight reporting in preclinical cachexia literature may alter study outcomes and interpretation

Disease Models & Mechanisms, 2023
Anna G. Beaudry, Michelle L. Law
doaj   +1 more source

Yet Another Compact Time Series Data Representation Using CBOR Templates (YACTS). [PDF]

Sensors (Basel), 2023
Molina Araque S, Martinez I, Papadopoulos GZ, Montavont N, Toutain L.   +4 more
europepmc   +1 more source

Condensed Representations for Data Mining [PDF]

, 2005
Condensed representations have been proposed in Mannila and Toivonen (1996) as a useful concept for the optimization of typical data-mining tasks. It appears as a key concept within the inductive database framework (Boulicaut et al., 1999; de Raedt, 2002; Imielinski & Mannila, 1996), and this article introduces this research domain, its ...
openaire   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Biological Ontologies and Semantic Biology

Frontiers in Genetics, 2014
John eHancock
doaj   +1 more source