Results 121 to 130 of about 846,245 (303)
Frontiers in Public HealthBackgroundPre-hospital emergency medical service (EMS) is essential in providing acute care services. This study aimed to analyze the characteristics and trends of pre-hospital EMS in Handan, China from 2011 to 2024 and provide references for the ...
Feng Tian +27 more
doaj +1 more source
, 2017 Presentation from the 2017 ESIP Summer Meeting, July 23, 2017, Bloomington, IN. Presented in the “Data Rescue” & ESIP session.
openaire +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Early Instrumental Weather Observations From Ukraine: The ClimUAsd‐Stn.v2 Dataset, 1808–1880
Geoscience Data JournalIn this study, we present ClimUAsd‐stn.v2, an updated publicly open version of the digital dataset of the earliest instrumental weather observation conducted in Ukraine.
Olesya Skrynyk +7 more
doaj +1 more source
Neurodegeneration in \u3cem\u3eDrop-Dead\u3c/em\u3e Mutant \u3cem\u3eDrosophila melanogaster\u3c/em\u3e Is Associated with the Respiratory System but Not with Hypoxia [PDF]
, 2013 Mutations in the gene drop-dead (drd) cause diverse phenotypes in adult Drosophila melanogaster including early lethality, neurodegeneration, tracheal defects, gut dysfunction, reduced body mass, and female sterility.
Blumenthal, Edward M +1 more
core +1 more source
Virtual-to-Real-World Transfer Learning for Robots on Wilderness Trails
, 2019 Robots hold promise in many scenarios involving outdoor use, such as search-and-rescue, wildlife management, and collecting data to improve environment, climate, and weather forecasting.
Iuzzolino, Michael L. +2 more
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Viewfinder: final activity report [PDF]
The VIEW-FINDER project (2006-2009) is an 'Advanced Robotics' project that seeks to apply a semi-autonomous robotic system to inspect ground safety in the event of a fire.
Penders, Jacques
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source