Results 131 to 140 of about 846,245 (303)

Construction and application of knowledge graph for urban agglomeration emergency rescue collaboration in earthquake disasters

Journal of Safety Science and Resilience
This study proposes an emergency rescue collaboration knowledge graph construction method for urban agglomeration in earthquake disasters. Based on the collection of 22 earthquake disaster emergency plans published on the official websites of multiple ...
Lin Zhang, Qichen Wang, Yanjun Guo, Xiangliang Tian, Lin Qi   +4 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

A marine data pipeline: data rescue to archive

Slides describing requirements for the development of a data pipeline feeding the full ouputs of data rescue (images, documentation, raw and processed data, metadata etc.) into the climate data system. Presently we lack an easy-to-use system to describe rescued and otherwise reprocessed observations in a systematic and transparent way.
Kent, Elizabeth, Cornes, Richard, 0009-0003-5558-2327, Joseph Siddons, Ward, Adam   +3 more
openaire   +1 more source

Guidelines on Best Practices for Climate Data Rescue.

, 2016
This technical document is an update of WMO/TD-1210, WCDMP-55, Guidelines on Climate Data Rescue (2004). It builds on the original Guidelines, while taking into account both changes in technology that have occurred in the intervening 12 years and lessons learned in more recent climate data rescue activities around the world.
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Review of the Application of UAV Edge Computing in Fire Rescue

Sensors
The use of unmanned aerial vehicles (UAVs) attracts significant attention, especially in fire emergency rescue, where UAVs serve as indispensable tools.
Hongqiang Sun, Rui Xu, Jianguo Luo, Han Cheng   +3 more
doaj   +1 more source

Collaborative information sensemaking for multi-robot search and rescue [PDF]

, 2015
In this paper, we consider novel information sensemaking methods for search and rescue operations that combine principles of information fusion and collective intelligence in scalable solutions.
Lee, PJ, Lewis, M, Zadorozhny, V
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source