Results 141 to 150 of about 846,245 (303)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Topology characteristics and robustness optimization of double layer rescue cooperation network of national mine emergency rescue team

Meitan kexue jishu
A systematic network model and quantitative robustness assessment are absent in the current layout and configuration of national emergency rescue teams for major mine accidents.
Wanbo ZHENG, Peiling ZHONG, Yanqing WU, Xu LI, Yueming KANG, Yongsheng TANG, Ruicheng ZHU   +6 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Muscone-specific olfactory protein MjavOBP3 identified as the putative scent-marking pheromone in the Sunda pangolin (Manis javanica)

Communications Biology
Pangolins are mammals of important conservation interest, as only eight extant species remain globally and all are considered to be at risk of extinction.
Zhongbo Yu, Tao Meng, Tengcheng Que, Luyao Yu, Yichen Zhou, Meihong He, Haijing Wang, Yingjiao Li, Liling Liu, Wenjian Liu, Yinliang Wang, Bingzhong Ren   +11 more
doaj   +1 more source

Biodiversity data rescue in the framework of a long-term Kenya-Belgium cooperation in marine sciences. [PDF]

Sci Data, 2019
Knockaert C, Tyberghein L, Goffin A, Vanhaecke D, Ong'anda H, Wakwabi EO, Mees J.   +6 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Soil legacy data rescue via GlobalSoilMap and other international and national initiatives. [PDF]

GeoResJ, 2017
Arrouays D, Leenaars JGB, Richer-de-Forges AC, Adhikari K, Ballabio C, Greve M, Grundy M, Guerrero E, Hempel J, Hengl T, Heuvelink G, Batjes N, Carvalho E, Hartemink A, Hewitt A, Hong SY, Krasilnikov P, Lagacherie P, Lelyk G, Libohova Z, Lilly A, McBratney A, McKenzie N, Vasquez GM, Leatitia Mulder V, Minasny B, Luca M, Odeh I, Padarian J, Poggio L, Roudier P, Saby N, Savin I, Searle R, Solbovoy V, Thompson J, Smith S, Sulaeman Y, Vintila R, Rossel RV, Wilson P, Zhang GL, Swerts M, Oorts K, Karklins A, Feng L, Ibelles Navarro AR, Levin A, Laktionova T, Dell'Acqua M, Suvannang N, Ruam W, Prasad J, Patil N, Husnjak S, Pasztor L, Okx J, Hallet S, Keay C, Farewell T, Lilja H, Juilleret J, Marx S, Takata Y, Kazuyuki Y, Mansuy N, Panagos P, Van Liedekerke M, Skalsky R, Sobocka J, Kobza J, Eftekhari K, Kacem Alavipanah S, Moussadek R, Badraoui M, Da Silva M, Paterson G, da Conceicao Gonsalves M, Theocharopoulos S, Yemefack M, Tedou S, Vrscaj B, Grob U, Kozak J, Boruvka L, Dobos E, Taboada M, Moretti L, Rodriguez D.   +88 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source