Results 231 to 240 of about 2,154,085 (300)

Tracking Trainee Movement: A Scalable Framework for Analyzing Geographic Retention in Graduate Medical Education. [PDF]

J Grad Med Educ
Garten B, Bhatt AN, Patel R, Nulu C, Vuppala R, Moumne M, Kotireddy V, Gohel I, Amjad M, Kirolos A, Yakoub D, Estes A.   +11 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Identification of Short Amino Acid Sequences That Correlate with Cytoplasmic Retention of Human Proteins. [PDF]

Cells
Brown JC, Wang B.
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Genetic elements promote retention of extrachromosomal DNA in cancer cells. [PDF]

Nature
Sankar V, Hung KL, Gnanasekar A, Wong IT, Shi Q, Kraft K, Jones MG, He BJ, Yan X, Belk JA, Liu KJ, Agarwal S, Wang SK, Henssen AG, Mischel PS, Chang HY.   +15 more
europepmc   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Analysis of Training Behavior in Users of a Fitness App: Cross-Sectional Study.

JMIR Mhealth Uhealth
Fuente-Vidal A, Prat R, Arribas-Marin JM, Bastidas-Jossa O, Guerra-Balic M, Garcia-Zapirain B, Montane J, Jerez-Roig J.   +7 more
europepmc   +1 more source

Gate insulator stack engineering for fully CMOS-compatible reservoir computing. [PDF]

Nano Converg
Hwang J, Park MK, Kim J, Bae JH, Lee JH.
europepmc   +1 more source

Secondary Forest Conversion Into Betel Nut Plantations Reduces Soil Water Retention by Altering Soil Properties. [PDF]

Ecol Evol
Fu R, Chen Q, Cheng S, Sun Z, Hu Z, Du Y, Dai L, Guo X.   +7 more
europepmc   +1 more source

The autonomy paradox in AI-generated content adoption: Creative-specific alternative to TAM model in China's micro-short drama industry. [PDF]

PLoS One
Tang C.
europepmc   +1 more source