Results 171 to 180 of about 4,603,530 (263)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Advancing data science research education in Africa through datathon-driven innovations. [PDF]

Sci Rep
Doumbia S, Kane F, Diabate O, Cisse C, Sanogo I, Coulibaly MD, Fofana FG, Delamou A, Beavogui AH, Thiam SM, Li J, Keïta M, Sogoba N, Tangara CO, Kakraba S, Wele M, Diakite M, Toure M, Shaffer JG.   +18 more
europepmc   +1 more source

R for Data Science

Journal of Statistical Software, 2017
Christopher Lortie
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Harnessing data science for health discovery and innovation in Africa (DS-I Africa). [PDF]

Commun Med (Lond)
Xiong C, Nakatumba Nabende J, Skelton M, Retshabile G, Wonkam A, Winters A, Kateete DP, Thaldar D, Agamah F, Amegah KA, Munung NS, Mulder N, Julius R, Chunara R, Fatumo S, Owolabi M.   +15 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Integrating data science for the analysis of early years health inequalities: a Birmingham, UK case study. [PDF]

BMC Med Inform Decis Mak
Haidar D, Tawil AH, Vilas J, Vlachos K, Clark M, Vakaj E, Sharratt N.   +6 more
europepmc   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Leveraging Longitudinal Data to Sustain the Impact of Organ Donation Training: A Data Science Approach to Quality Monitoring. [PDF]

J Transplant
Ghobadi O, Taherkhani N, Khasha R, Radi E, Shadnoush M, Najafizadeh K.   +5 more
europepmc   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source