Results 171 to 180 of about 13,846,560 (292)

Data science without borders: bridging the divide in data science capacity across African health institutions. [PDF]

Front Public Health
Kiragga AN, Iddi S, Walekhwa AW, Barasa M, Cygu S, Odhiambo R, Gningue M, Mboup A, Onana A, Adnew B, Alemu Ashuro A, Hudson S, Greenfield J, Todd J, Bhattacharjee T, Sharan M, Sonabend R, Kadengye D, Mbatchou BH, Abdissa A, Sarr M, Nabende JN, Bamutura M, Tamurat B, Dereje N, Temfack E.   +25 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Qualitative Framework for Evaluating Clinical Data Science Systems: Beyond Technical Validation. [PDF]

Healthc Inform Res
Heslin SM.
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

A Framework and Method for Measuring the Implementation of Data Science in Critical Care. [PDF]

Crit Care Explor
Woznica D, Al-Hakim T, Kumar VK, Cobb JP, Kamaleswaran R, Khanna AK, Laudanski K, Zimmerman JJ, Reuter-Rice K.   +8 more
europepmc   +1 more source

Quantifying Biomedical Data Reuse in an Open Science Ecosystem [PDF]

, 2019
Federer, Lisa
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Posttraumatic stress in young children at risk for maltreatment: a causal data science analysis. [PDF]

Front Health Serv
Saxe GN, Morales LJ, Ma S, Urgurbil M, Aliferis C.   +4 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Beyond the dataset: integrating public voices in data science. [PDF]

Res Involv Engagem
Rubio AP, Dunn J, Borthwick J, Saunders S, Tochel C, Anderson H, Coull L, Javidi M, Cloete H, McTrusty A, Penny J, MacGillivray T, Tatham AJ, Jackson T, Porteous C, Strang N, Dhillon B, Bernabeu MO.   +17 more
europepmc   +1 more source