Results 271 to 280 of about 13,729,805 (320)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Application of data science methods, including machine learning, in the classification of focal lesions in the thyroid gland. [PDF]

open access: yesJ Ultrason
Gadzicki PM   +6 more
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

open access: yesMolecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek   +2 more
wiley   +1 more source

Data science applied to the assessment of biological variation estimates. [PDF]

open access: yesAdv Lab Med
Marques-Garcia F   +4 more
europepmc   +1 more source

Ethical governance for genomic data science in the cloud. [PDF]

open access: yesNat Rev Genet
Rahimzadeh V   +4 more
europepmc   +1 more source

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