Results 131 to 140 of about 32,417,955 (343)
The SPHERE data center: a reference for high contrast imaging processing [PDF]
, 2017 The objective of the SPHERE Data Center is to optimize the scientific return of SPHERE at the VLT, by providing optimized reduction procedures, services to users and publicly available reduced data. This paper describes our motivation, the implementation
Albert, D. +21 more
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Load Balancing and Virtual Machine Allocation in Cloud-based Data Centers [PDF]
, 2018 As cloud services see an exponential increase in consumers, the demand for faster processing of data and a reliable delivery of services becomes a pressing concern. This puts a lot of pressure on the cloud-based data centers, where the consumers’ data is
Ghodke, Saily Satish
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Mediated data integration and transformation for web service-based software architectures [PDF]
, 2006 Service-oriented architecture using XML-based web services has been widely accepted by many organisations as the standard infrastructure to integrate heterogeneous and autonomous data sources.
Pahl, Claus, Zhu, Yaoling
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Resilient by Design: Assessment Strategies for Data Services from RDAP 2025
Journal of eScience LibrarianshipThe RDAP Summit 2025 theme of Evolutions in Data Services: Forging Resiliency prompted a range of presentations focused on using assessment to help libraries develop more responsive and sustainable research data services.
Rose Fredrick
doaj +2 more sources
Need for Human Services in Illinois [PDF]
, 2011 This report aims to support the Illinois Human Services Commission in its effort to fulfill its charge to "undertake a systematic review of human services programs with the goal of ensuring their consistent delivery in the State of Illinois" and to "make
Amy Terpstra, Ellyn Drathring
core