Results 131 to 140 of about 24,469,419 (259)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The Classification of Building Functional Types Using a Multihop GNN Constrained With Street Boundaries From High-Resolution Satellite Images

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Existing methods for recognizing building functions from high-resolution satellite images insufficiently capture spatial structural relationships between buildings, particularly in densely populated urban areas. This issue reduces the distinguish ability
Xiaojiao Cai, Mengmeng Li, Mengjing Lin, Kangkai Lou   +3 more
doaj   +1 more source

Sharing Data and Models in Software Engineering Sharing Data and Models

, 2015
Data Science for Software Engineering: Sharing Data and Models presents guidance and procedures for reusing data and models between projects to produce results that are useful and relevant.
Turhan, Burak, Peters, Fayola, Minku, Leandro, Menzies, Tim, Kocaguneli, Ekrem   +4 more
core  

Prepublication data sharing

, 2009
Rapid release of prepublication data has served the field of genomics well. Attendees at a workshop in Toronto recommend extending the practice to other biological data sets.http://dx.doi.org/10.1038 ...
Brookes, Anthony J., Green, Eric D., Harris, Jennifer R., Gunter, Chris, Hudson, Thomas J., Eddy, Sean, Austin, Christopher P., Ehrlich, S. Dusko, Birney, Ewan, Apweiler, Rolf, Rogers, Jane, Bountra, Chas, Berglund, Lisa, Bobrow, M., Cambon-Thomsen, An   +14 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Modernizing the Design Process for US Organ Allocation Policy: Toward a Continuous Distribution Policy for Kidneys

Transplantation Direct
Background. The allocation of a limited supply of donor organs remains a critical challenge for organ transplantation. The analytical tools that policymakers rely upon for improving allocation policy have seen little advancement since the introduction of
Elijah Pivo, PhD(c), James Alcorn, JD, Dimitris Bertsimas, PhD, Sarah E. Booker, MPH, Keighly Bradbrook, PhD, Thomas G. Dolan, MS, Lindsay V. Larkin, BA, Kayla R. Temple, BA, Nikolaos Trichakis, PhD   +8 more
doaj   +1 more source

Cross-Cutting Trust Frameworks to Support Data Sharing Across Communities

The increasing need for cross-sectoral, cross-border, and cross-domain, i.e. cross-community, data sharing calls for harmonization of trust and trust frameworks across data spaces (or, in general, data sharing communities).
Farias Lóscio, B., Bastiaansen, H.J.M., Bouman, E., Haijenga, F.   +3 more
core  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Ecological data sharing

Ecological Informatics, 2015
AbstractData sharing is the practice of making data available for use by others. Ecologists are increasingly generating and sharing an immense volume of data. Such data may serve to augment existing data collections and can be used for synthesis efforts such as meta-analysis, for parameterizing models, and for verifying research results (i.e., study ...
openaire   +1 more source

Solutions to COVID-19 data sharing [PDF]

, 2020
Fegan, Greg, Cheah, Phaik Yeong
core   +1 more source