Results 211 to 220 of about 3,643,121 (304)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Data Management and Data Sharing Training in Social Science Graduate Programs, United States, 2017-2018

, 2017
Ashley Doonan
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Navigating open data sharing and privacy in the age of clinical AI research: from reidentification to pseudo-reidentification. [PDF]

EClinicalMedicine
Hallaj S, Heinke A, Kalaw FGP, Gim N, Blazes M, Owen J, Dysinger E, Benton ES, Cordier BA, Evans NG, Li-Pook-Than J, Snyder MP, Nebeker C, Zangwill LM, Baxter SL, McWeeney S, Lee CS, Lee AY, Patel B, AI-READI Consortium.   +19 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Education researchers' beliefs and barriers towards data sharing. [PDF]

Qual Quant
Logan JAR, Hayward AL, Swanz LE, Ceviren AB.   +3 more
europepmc   +1 more source

Survey on User Group Revocation and Integrity Auditing of Shared Data in Cloud Environment

, 2018
Rohit Rai, Upasna Singh
openalex   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

A reinforcement learning-based approach for dynamic privacy protection in genomic data sharing beacons. [PDF]

Genome Biol
Poorghaffar Aghdam M, Shukueian Tabrizi S, Ayöz K, Ayday E, Sav S, Çiçek AE.   +5 more
europepmc   +1 more source

Regional digital economy development and enterprise ESG performance —— comes from the empirical analysis of the panel data of Chinese A-share listed companies

Jingyan Wang
openalex   +2 more sources