Results 61 to 70 of about 384,420 (258)
CoRRIn a previous work, "pure data" is proposed as an axiomatic foundation for mathematics and computing, based on "finite sequence" as the foundational concept rather than based on logic or type. Within this framework, objects with mathematical meaning are "data" and collections of mathematical objects must then be associative data, called a "space." A ...
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FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
What are “personal data spaces”?
Companion Proceedings of the ACM Web Conference 2023, 2023 Peer ...
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A Data Connector Store for International Data Spaces
, 2022 The International Data Spaces Association (IDSA) has promoted the idea of International Data Spaces as a place for companies to share data with trust and security enforced by software and organizational competence. There has been considerable progress in delivering corporate guidelines, technical specifi- cations, and software components available for ...
Danniar Reza Firdausy +3 more
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Towards a minimum viable dataspace for the CEDS public sector: An initial implementation
Data in BriefData sharing across borders and sectors has emerged as a main priority for Europe. Common European Data Spaces (CEDS) aim to make this possible in a trusted, secure, and interoperable way.
Anastasios Nikolakopoulos +5 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source