Results 61 to 70 of about 23,724,259 (306)

Fostering Interdisciplinary Data Cultures through Early Career Development: The RDA/US Data Share Fellowship

Data Science Journal, 2021
Openness and interdisciplinarity in research and data are among the challenges that are frequently discussed in the context of changing scientific and scholarly practices.
Inna Kouper, Lois A. Scheidt, Beth A. Plale   +2 more
doaj   +1 more source

Calcineurin‐Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in Candida Glabrata

Advanced Science, EarlyView.
Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su, Yi Li, Meng Xiao, Dan Guo, David S. Perlin, Erika Shor, Yingchun Xu, Yingxing Li   +7 more
wiley   +1 more source

Stewardship Maturity Assessment Tools for Modernization of Climate Data Management

Data Science Journal, 2021
High quality and well-managed climate data are the cornerstone of all climate services. Consistently assessing how well the data are managed is one way to establish or demonstrate the trustworthiness of the data.
Robert Dunn, Christina Lief, Ge Peng, William Wright, Omar Baddour, Markus Donat, Brigitte Dubuisson, Jean-François Legeais, Peter Siegmund, Reinaldo Silveira, Xiaolan L. Wang, Markus Ziese   +11 more
doaj   +1 more source

Rapid Multiplex Antimicrobial Resistance Profiling and Bacterial Identification by LAP‐MALDI Mass Spectrometry Biotyping

Advanced Science, EarlyView.
Liquid atmospheric pressure matrix‐assisted laser desorption/ionization (LAP‐MALDI) mass spectrometry (MS) provides multiplexed biotyping of microbial cultures using a fast and simple workflow. This is demonstrated for clinically relevant bacteria, resulting in accurate antimicrobial resistance (AMR) detection, speciation by MS/MS sequencing and ...
Lily R. Adair, Shabnam Iyer, Ian M. Jones, Rainer Cramer   +3 more
wiley   +1 more source

How FAIR Is Bioarchaeological Data: With a Particular Emphasis on Making Archaeological Science Data Reusable

Journal of Computer Applications in Archaeology
Archaeology is witnessing an exponential rise in data generation, and this can be particularly seen in the field of bioarchaeology which encompasses ancient DNA, osteoarchaeology, paleopathology, palaeoproteomics, stable isotopes, and zooarchaeology ...
Alphaeus Lien-Talks
doaj   +1 more source

Perspective: The Power (Dynamics) of Open Data in Citizen Science

Frontiers in Climate, 2021
In citizen science, data stewards and data producers are often not the same people. When those who have labored on data collection are not in control of the data, ethical problems could arise from this basic structural feature.
Caren B. Cooper, Lisa M. Rasmussen, Elizabeth D. Jones   +2 more
doaj   +1 more source

Recommendations for Data Stewardship Skills, Training and Curricula with Implementation Examples from European Countries and Universities [PDF]

Data stewards, who plan, manage and maintain the data of a research unit, are skilled professionals essential in bringing about a culture change for data management, sharing research data, and developing infrastructures and data policies.
KUCHMA, Iryna, FORNI, Monica, KALOVÁ, Tereza, Ilire Hasani-Mavriqi, Núria Raga, Jaana Pinnick, RAGA RAGA, Núria, THORPE, Deborah, Iryna Kuchma, HASANI-MAVRIQI, Ilire, Hanna Lindroos, Lorna Wildgaard, BASALTI, Chiara, JANIK, Joanna, Judit Fazekas-Paragh, VAN GELDER, Celia, Joanna Janik, Tereza Kalová, PINNICK, Jaana, Monica Forni, WILDGAARD, Lorna, Deborah Thorpe, LÜTCKE, Henry, Celia van Gelder, FAZEKAS-PARAGH, Judit, Henry Lütcke, Chiara Basalti, LINDROOS, Hanna   +27 more
core   +1 more source

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

IFI27 and BAX are Essential for GSDME‐Mediated Myeloma Cell Pyroptosis

Advanced Science, EarlyView.
The proposed model of GSDME‐mediated MM cell pyroptosis modulated by IFI27 and BAX. IFI27 is downregulated in MM cells. Upon pyroptotic stimulation, such as DOX or ETO treatment, IFI27 is induced, therefore liberating BAX from BCL‐2 ❶. BAX is then recruited to mitochondria and forms homo‐oligomeric channels in OMM, therefore leading to cytochrome C ...
Yaoli Cui, Yuening Sun, Ziyang Liu, Xuntao Lai, Yunshu Zhao, Yan'er Wang, Yuanming He, Fang Xu, Du Feng, Longlong Liu, Zhenqian Huang, Lijie Xing, Xinliang Mao   +12 more
wiley   +1 more source

Uncertainty quantification in machine learning models on synchrotron diffraction patterns

Machine Learning. Engineering
Machine learning (ML) models have been widely used to study functional relationships between attributes in physical science, engineering, medical science, social science, and other areas.
Ayorinde E Olatunde, Weiqi Yue, Gabriel Ponon, Donald W Brown, Roger H French, Pawan K Tripathi, Anirban Mondal   +6 more
doaj   +1 more source