Results 271 to 280 of about 6,963,647 (337)

Location-based Data Analysis of Visitor Structure for Recreational Area Management

, 2020
Chieh-Ping Wu, Shao-Hsun Wang, Hsuan Chiu, Peixun Wang, Chia-Hu Chang, Pei-Chi Sun, Wenqian Chen, Hsiao-Wei Sung, Hsiao-Hui Chen   +8 more
openalex   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Impact of Spatial structure of urban agglomerations on green innovation in China. [PDF]

Sci Rep
Dong S, Liu K.
europepmc   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Comparative evaluation of the prediction accuracy of AlphaFold and ESMFold for monomeric and dimeric proteins. [PDF]

NAR Genom Bioinform
Mahtha SK, Venkadesan S, Mohanty D.
europepmc   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Guest Editorial: Smart cities 2.0: How Artificial Intelligence and Internet of Things are transforming urban living

IET Smart Cities
Zheng‐Yi Chai, Syed Attique Shah, Dirk Draheim, Sufian Hameed, Muhammad Mazhar Ullah Rathore   +4 more
doaj   +1 more source

Towards patient-relevant structures: reviewing body-temperature biological macromolecules and their ligands for pharmaceutical applications. [PDF]

Acta Crystallogr D Struct Biol
Brink A, Helliwell JR, Jacobs FJF.
europepmc   +1 more source

Inverse design of cellular structures with the targeted nonlinear mechanical response. [PDF]

Sci Rep
Nakarmi S, Daphalapurkar NP, Lee KS, Kim J, Leiding JA, Dattelbaum DM, Luscher DJ.   +6 more
europepmc   +1 more source