Results 111 to 120 of about 15,768,589 (336)
Improving the management of type 2 diabetes through large-scale general practice: the role of a data-driven and technology-enabled education programme [PDF]
, 2021 Tarek Radwan +7 more
openalex +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Zhongguo shuxue zazhiObjective To establish an information management platform for provincial rare blood group bank to achieve the interconnection and sharing of data such as rare blood group types, donor information and blood inventory, so as to enhance the supply security ...
Junna QIU +6 more
doaj +1 more source
Two-Higgs-doublet model of type II confronted with the LHC run I and run II data [PDF]
, 2017 Lei Wang, Feng Zhang, Xiao-Fang Han
openalex +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Advancing Spectral Clustering for Categorical and Mixed-Type Data: Insights and Applications
MathematicsThis study focuses on adapting spectral clustering, a numeric data-clustering technique, for categorical and mixed-type data. The method enhances spectral clustering for categorical and mixed-type data with novel kernel functions, showing improved ...
Cinzia Di Nuzzo
doaj +1 more source
Inferring Road Intersection Control Type from GPS Data
Findings, 2022 Transport modelling requires accurate and usually hard to find intersection control rules. The widespread of smartphone applications enabled the automatic collection of road network-related data that can contribute to and improve transport modelling ...
Adham Badran +2 more
doaj
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source