Results 121 to 130 of about 44,292,339 (363)
Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation
FEBS Letters, EarlyView.The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt +8 more
wiley +1 more source
SMS design review plan, type 1 data [PDF]
The SMS PDR plan is submitted incrementally 15 days prior to the associated PDR's.
core +1 more source
On the assimilation of SWOT type data into 2D shallow-water models [PDF]
, 2013 In river hydraulics, assimilation of water level measurements at gauging stations is well controlled, while assimilation of images is still delicate. In the present talk, we address the richness of satellite mapped information to constrain a 2D shallow ...
Couderc, Frédéric +5 more
core
A deep learning mixed-data type approach for the classification of FHR signals. [PDF]
Front Bioeng Biotechnol, 2022 Spairani E +3 more
europepmc +1 more source
Cell type prioritization in single-cell data
Nature Biotechnology, 2019 We present Augur, a method to prioritize the cell types most responsive to biological perturbations in single-cell data. Augur employs a machine-learning framework to quantify the separability of perturbed and unperturbed cells within a high-dimensional ...
M. Skinnider +13 more
semanticscholar +1 more source
Purification tags markedly affect self‐aggregation of CPEB3
FEBS Letters, EarlyView.Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito +6 more
wiley +1 more source
Deep learning facilitates multi-data type analysis and predictive biomarker discovery in cancer precision medicine. [PDF]
Comput Struct Biotechnol J, 2023 Mathema VB +4 more
europepmc +1 more source
mixOmics: An R package for ‘omics feature selection and multiple data integration
bioRxiv, 2017 The advent of high throughput technologies has led to a wealth of publicly available ‘omics data coming from different sources, such as transcriptomics, proteomics, metabolomics.
F. Rohart +3 more
semanticscholar +1 more source
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
Improving a data-acquisition software system with abstract data type components [PDF]
data types and object-oriented design are active research areas in computer science and software engineering. Much of the interest is aimed at new software development.
Howard, S. D.
core +1 more source