Results 121 to 130 of about 45,779,043 (381)

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

A deep learning mixed-data type approach for the classification of FHR signals. [PDF]

Front Bioeng Biotechnol, 2022
Spairani E, Daniele B, Signorini MG, Magenes G.   +3 more
europepmc   +1 more source

Accurate estimation of cell-type composition from gene expression data

Nature Communications, 2019
The rapid development of single-cell transcriptomic technologies has helped uncover the cellular heterogeneity within cell populations. However, bulk RNA-seq continues to be the main workhorse for quantifying gene expression levels due to technical ...
Daphne M Tsoucas, R. Dong, Haide Chen, Qian Zhu, Guoji Guo, Guocheng Yuan   +5 more
semanticscholar   +1 more source

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

FEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki, Masae Ohtsuka, Takeshi Nakano, Masaru Tanokura, Takuya Miyakawa   +4 more
wiley   +1 more source

Deep learning facilitates multi-data type analysis and predictive biomarker discovery in cancer precision medicine. [PDF]

Comput Struct Biotechnol J, 2023
Mathema VB, Sen P, Lamichhane S, Orešič M, Khoomrung S.   +4 more
europepmc   +1 more source

Empirical data on age and position in the Hertzsprung-Russell diagram for O and B-type stars [PDF]

, 1959
A. Blaauw
openalex   +1 more source

ACSS2 involved in acetyl‐CoA synthesis regulates skeletal muscle function

FEBS Letters, EarlyView.
The enzyme acyl‐coenzyme A synthetase short‐chain family member‐2 (ACSS2) catalyzes the conversion of acetate to acetyl‐CoA, but its function in skeletal muscle is unclear. We studied ACSS2 deficiency in mouse and fly models. Skeletal muscle from the mouse model showed atrophic fibers, excess lipid, and depleted NADH.
Mekala Gunasekaran, Gloriana Campos, Natalya M. Wells, Khanhlinh Lambuu, Isabelle Draper, Christina A. Pacak, Peter B. Kang   +6 more
wiley   +1 more source

Cell type prioritization in single-cell data

Nature Biotechnology, 2019
We present Augur, a method to prioritize the cell types most responsive to biological perturbations in single-cell data. Augur employs a machine-learning framework to quantify the separability of perturbed and unperturbed cells within a high-dimensional ...
M. Skinnider, J. Squair, C. Kathe, Mark A. Anderson, M. Gautier, K. Matson, M. Milano, T. Hutson, Q. Barraud, A. Phillips, L. Foster, Gioele La Manno, Ariel J. Levine, G. Courtine   +13 more
semanticscholar   +1 more source

A working model for cytoplasmic assembly of H/ACA snoRNPs

FEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

PRESSURE-HEIGHT PREDICTABILITY AS A FUNCTION OF THE TYPE AND AMOUNT OF INITIAL DATA [PDF]

, 1956
Robert M. White
openalex   +1 more source