Results 81 to 90 of about 45,779,043 (381)
Purification tags markedly affect self‐aggregation of CPEB3
FEBS Letters, EarlyView.Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito +6 more
wiley +1 more source
Pengaruh Type Penyajian Data dan Gaya Kognitif
Teknologi dan Kejuruan, 2016 Pengaruh Type Penyajian Data dan Gaya ...
Waras Waras
doaj +1 more source
A Logic for Abstract Data Types as Existential Types [PDF]
, 1999 The second-order lambda calculus allows an elegant formalisation of abstract data types (ADT's) using existential types. Plotkin and Abadi's logic for parametricity [PA93] then provides the useful proof principle of simulation for ADT's, which can be used to show equivalence of data representations.
Erik Poll, Jan Zwanenburg
openaire +3 more sources
Single‐cell insights into the role of T cells in B‐cell malignancies
FEBS Letters, EarlyView.Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
LASSO type penalized spline regression for binary data
BMC Medical Research Methodology, 2021 Background Generalized linear mixed models (GLMMs), typically used for analyzing correlated data, can also be used for smoothing by considering the knot coefficients from a regression spline as random effects.
Muhammad Abu Shadeque Mullah +2 more
doaj +1 more source
FEBS Letters, EarlyView.The amyloid world hypothesis of the origin‐of‐life posits that the first functional polymers on the early Earth were structurally stable cross‐β‐sheet‐based peptide amyloids capable of Darwinian‐like evolution. Peptide amyloids display self‐replication and information transfer, as well as catalytic, adaptive, and evolutive properties.
Carl Peter J. Maury
wiley +1 more source
Determining cell-type abundance and expression from bulk tissues with digital cytometry
Nature Biotechnology, 2019 Single-cell RNA-sequencing has emerged as a powerful technique for characterizing cellular heterogeneity, but it is currently impractical on large sample cohorts and cannot be applied to fixed specimens collected as part of routine clinical care.
Aaron M. Newman +11 more
semanticscholar +1 more source
RMD OpenObjective To identify blood-based predictive and pharmacodynamic biomarkers at different timepoints in patients with active rheumatoid arthritis (RA) treated with anti-interleukin-6 receptor (anti-IL-6R) and anti-tumour necrosis factor-α (anti-TNF-α ...
Emilie Gerard +11 more
doaj +1 more source
Data gathering for science and research
Agricultural Economics (AGRICECON), 2004 Reasoning and argumentation in empirical sciences and research is based on row data and the intermediate and final structures, calculations etc., derived from the raw data.
J. Vaníček
doaj +1 more source
Brain Data Standards - A method for building data-driven cell-type ontologies
Scientific Data, 2023 Large-scale single-cell ‘omics profiling is being used to define a complete catalogue of brain cell types, something that traditional methods struggle with due to the diversity and complexity of the brain.
Shawn Zheng Kai Tan +19 more
doaj +1 more source