Results 101 to 110 of about 88,910 (290)
Advanced Science, EarlyView.A large‐scale multiomic dataset (proteomic and metabolomic) comprising 3,060 plasma samples were analyzed to identify proteins, metabolites, pathways, and protein‐associated drugs linked to Alzheimer’s Disease (AD) independently of apolipoprotein E (APOE). AD was associated with a distinct molecular signature that captures.
Fuhai Li +22 more
wiley +1 more source
KDM4A Erases the H3R17me2a Mark, Facilitating Chromosome Condensation
Advanced Science, EarlyView.This study reveals a reversible histone modification switch governing chromosome condensation during mitosis. PKCα‐activated KDM4A removes H3R17me2a, permitting Suv39h1‐driven H3K9me3 deposition. This epigenetic transition recruits the chromosomal passenger complex and triggers Aurora B‐dependent H3S10 phosphorylation, coordinating chromatin remodeling
Yena Cho +6 more
wiley +1 more source
Challenges and Opportunities of Clinical Data Warehousing
Applied Medical InformaticsClinical data warehousing (CDW) aims to provide an integrated database for secondary health analysis. We conducted a rapid review including 22 studies published between 2018 and 2022 that reported CWD implementation details in addition to individual ...
Niklas GIESA +6 more
doaj
DATA WAREHOUSES – MODELS, TECHNIQUES AND APPLICATIONS
TASK Quarterly, 2011 This paper discusses the basic concepts of modern data warehouses. It presents the multidimensional data model (logical model) and the physical model of a data warehouse, as well as selected design and implementation issues.
KRZYSZTOF GOCZYŁA
doaj
Material‐Induced Nuclear Deformation Controls Chromatin Architecture in Adipose Stem Cells
Advanced Science, EarlyView.Tuning cell and cytoskeleton mechanics modulated nuclear shape and heterochromatin organization in ASCs. Distinct cytoskeletal architectures induced nuclear morphologies from oblate to prolate ellipsoids. Large elongated cells with a structured actin cap exhibited high nuclear strain, driving nuclear envelope deformation and heterochromatin ...
Carlo F. Natale +6 more
wiley +1 more source
A Historical Shift Share Analysis for Georgia [PDF]
, 2006 This report analyzes the trends in Georgia's industrial composition and employment over the period 1970-2000 using shift share analysis.
Peter Bluestone
core
Advanced Science, EarlyView.This work develops dynamically softening polyacrylamide hydrogels for time‐resolved imaging during continuous mechanical transitions. The study revealed that mechanotransduction is biphasic; YAP/TAZ inactivation is driven by early loss of the nucleocytoskeletal continuum connecting subnuclear adhesions, F‐actin, and the nuclear envelope, coupled with ...
Alessandro Gandin +12 more
wiley +1 more source
Extracting, Transforming and Archiving Scientific Data [PDF]
, 2011 It is becoming common to archive research datasets that are not only large but also numerous. In addition, their corresponding metadata and the software required to analyse or display them need to be archived. Yet the manual curation of research data can
Lemire, Daniel, Vellino, Andre
core +1 more source
Lipid‐Facilitated Opening of the ADAM10 Sheddase Revealed by Enhanced Sampling Simulations
Advanced Science, EarlyView.Phosphatidylserine acts as a lipid trigger to enhance activation of the sheddase ADAM10. By integrating fluorescence spectroscopy assays with enhanced sampling molecular dynamics simulations, this study shows that phosphatidylserine promotes ADAM10 catalytic activity along with expansion of its extracellular domains, enhancing accessibility to scaffold
Adrien Schahl +7 more
wiley +1 more source
Social Sciences and Humanities OpenThis study investigates the relationships between pricing, distribution, warehousing strategies, consumer demand, and purchase decisions in Indonesia. This study employs a quantitative methodology, including data collected from 160 respondents from 60 ...
Ika Pratiwi +4 more
doaj +1 more source