Results 111 to 120 of about 6,882,714 (305)
Automated Rooftop Solar Panel Detection Through Convolutional Neural Networks
Canadian Journal of Remote SensingTransforming the global energy sector from fossil-fuel based to renewable energy sources is crucial to limiting global warming and achieving climate neutrality.
Simon Pena Pereira +2 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
A database of locus-specific databases [PDF]
Nature Genetics, 2007 Ourania, Horaitis +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
DB[11]Database System Development Lifecycle
, 2012 [[abstract]]Database System Development ...
王學亮
core
, 2017 Geographic range is used as a correlate of extinction risk for extant and extinct organisms across the fields of conservation and paleobiology. However, the exact method used to measure geographic range, the biases, and the limitations of each are rarely
Paleobiology Database (8021204) +1 more
core +1 more source
, 2000 Search engines are currently the standard medium for locating and accessing information on the Web. However, they may not scale to match the anticipated explosion of Web content since they support only extremely coarse-grained queries and are based on centralized architectures.
openaire +2 more sources
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Vectorwise: Beyond Column Stores [PDF]
, 2012 This paper tells the story of Vectorwise, a high-performance analytical database system, from multiple perspectives: its history from academic project to commercial product, the evolution of its technical architecture, customer reactions to the product ...
Zukowski, Marcin +6 more
core +2 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source