Results 151 to 160 of about 16,551,161 (356)

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

open access: yesMolecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban   +12 more
wiley   +1 more source

Subquery allocations in distributed databases using genetic algorithms

open access: yesJournal of Computer Science and Technology, 2010
Minimization of query execution time is an important performance objective in distributed databases design. While total time is to be minimized for On Line Transaction Processing (OLTP) type queries, response time has to be minimized in Decision Support ...
Narasimhaiah Gorla, Suk-Kyu Song
doaj  

Microglia limit brain tumor development by restricting tumor cell proliferation and inducing T‐cell immunity

open access: yesMolecular Oncology, EarlyView.
Microglia (BV2) and IL‐4‐treated BMDMs promote astrocytoma clustering and inhibit tumor growth, not shown in other macrophage cells. In vivo, microglial co‐implantation enhances CD8+ T cell infiltration, elevates Granzyme B, lowers circulating MDSCs, and extends survival only in immune‐competent mice, but not in immune‐deficient mice.
Tzu‐Chieh Sun   +5 more
wiley   +1 more source

Design and implementation of national security vulnerability database

open access: yesTongxin xuebao, 2011
Base on both domestic and overseas research on vulnerability database,considering our national conditions and the security requirements,a security vulnerability database model was proposed.It’s compatible with multiple stan-dards,and could be used to ...
ZHANG Yu-qing1   +3 more
doaj   +2 more sources

A design tool for object oriented databases [PDF]

open access: bronze, 1990
Mokrane Bouzeghoub   +3 more
openalex   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

open access: yesMolecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy   +9 more
wiley   +1 more source

Identifying prognostic targets in metastatic prostate cancer beyond AR

open access: yesFEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng   +13 more
wiley   +1 more source

Identifying and addressing common undergraduate database design misconceptions

open access: yesFrontiers in Education
Data are a crucial asset for organizations, making it essential for database designers to effectively organize and manage data using DataBase Management Systems (DBMS).
Noha Abdelaziz   +3 more
doaj   +1 more source

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