Results 271 to 280 of about 16,551,161 (356)

Targeting RAGE with Nanobodies for Molecular Imaging of Cancers and Alzheimer's Disease

Advanced Biology, EarlyView.
RAGE‐specific nanobodies were isolated via phage display and characterized by ELISA, cell ELISA, and SPR. In vivo imaging in renal carcinoma and Alzheimer's disease mouse models demonstrated that NbF8, the highest‐affinity clone, selectively targeted RAGE‐overexpressing tumors and brain tissues, highlighting its potential as a molecular imaging agent ...
Guangfeng Liang, Fujing Wang, Wei Xiong, Guangwei Shi, Junling Yuan, Yang Li, Hongyan Zhang, Yanmei Xing, Shan Jin, Kongjun Yang, Zhongliang Dai, Jichao Sun, Zhijie Li, Jianhong Wang   +13 more
wiley   +1 more source

A study on the Database for an Extrusion Process Design : Influence of the hole form in port hole die extrusion

, 2002
Kenichi MATUZAWA, Yukihiko Uchida, Michihiko Hoshino   +2 more
openalex   +2 more sources

Targeting SPATS2 in lung adenocarcinoma: implications for prognosis and immune-based therapy. [PDF]

Discov Oncol
Teng M, Yan F, Shang J, Sun X, Wang Y, Shen J.   +5 more
europepmc   +1 more source

LIN28B Promotes Cancer Cell Dissemination and Angiogenesis

Advanced Biology, EarlyView.
Children diagnosed with high‐risk neuroblastoma have a 5‐year event‐free survival rate of less than 50% and poor outcomes after recurrence. Deregulation of the LIN28B oncogene can be addressed in these patients. Upregulation of LIN28B is shown to support the metastatic cascade.
Diana Corallo, Sara Menegazzo, Marcella Pantile, Silvia Bresolin, Carlo Zanon, Alessandro Davini, Massimiliano Mazzone, Alessandra Biffi, Sanja Aveic   +8 more
wiley   +1 more source

Design and Analysis of Active Hypertext Views on Databases

, 2003
Gilles Falquet, Jacques Guyot, Luka Nerima, Seongbin Park   +3 more
openalex   +2 more sources

Structural Bias in Three-Dimensional Autoregressive Generative Machine Learning of Organic Molecules. [PDF]

J Chem Inf Model
Koczor-Benda Z, Gilkes J, Bartucca F, Al-Fekaiki A, Maurer RJ.   +4 more
europepmc   +1 more source

Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment

Advanced Biology, EarlyView.
The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li, Sepehr Akhtarkhavari, Sumeng Qi, Jiawei Fan, Tu‐Yung Chang, Yao‐An Shen, JinMing Yang, Barbara S. Slusher, Ie‐Ming Shih, Stephanie Gaillard, Tian‐Li Wang   +10 more
wiley   +1 more source

Predicting interacting hotspots for nanobodies' binding using triplets of residues. [PDF]

Protein Sci
Hamdani R, Cianferoni D, Reche R, Delgado J, Serrano L.   +4 more
europepmc   +1 more source

HMGB1 Derived from the Pyroptotic Microenvironment Promotes Macrophage Extracellular Traps in Hirschsprung‐Associated Enterocolitis

Advanced Biology, EarlyView.
HMGB1 derived from the pyroptotic environment in Hirschsprung‐associated enterocolitis mediates the formation of macrophage extracellular traps through TLR4 ‐p38 MAPK/p65 NF‐kB signaling pathways. Macrophage extracellular traps induce increased ROS production and pyroptosis of colonic epithelial cells.
Rui Zhang, Jing Li, Lili Song, Liya Pan, Chengchen Zhang, Zhiyan Zhan, Li Hong   +6 more
wiley   +1 more source

Epidemiological profiles and intervention strategies of limb deformities in China: A nationwide study based on the largest orthopedic database in China. [PDF]

J Orthop Translat
Guo B, Qin S, Zhang J, Wang Y, Shi L.
europepmc   +1 more source