Results 141 to 150 of about 10,674,355 (324)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Epidemiology of high-energy trauma in Chile: An ecological analysis using public registries
MedwaveHigh-energy trauma is defined as severe organic injuries resulting from events that generate a large amount of kinetic, electrical, or thermal energy. It represents a significant public health concern, accounting for 10% of global mortality. This article
Maximiliano Barahona +4 more
doaj +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Trends in Zombie Firms Research: A Bibliographic Review
Studies in Business and EconomicsThe aim of the paper is to explore the knowledge infrastructure of research addressing the zombie issue using a bibliometric review approach combined with content analysis.
Blažková Ivana +2 more
doaj +1 more source
BANK DEBT AND MARKET DEBT: AN EMPIRICAL ANALYSIS FOR SPANISH FRIMS [PDF]
This paper examines the effect on the firm’s banking cost of the issue of debt securities. We argue over the existence of a positive relationship between the issue of market debt and the reduction of firm’s banking cost.
Josep A. Tribó, María J. Casasola
core
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Improving SQL Server Perform [PDF]
With the development of client server technology and multilayer architectures the systems ef-ficiency issue has been increasingly discussed. Lacking knowledge in optimization methods and tools offered by DBMS's, database administrators and developers of ...
Nicolae MERCIOIU, Victor VLADUCU
core
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
A dataset of the representatives elected in France during the fifth republicZenodo
Data in BriefThe electoral system is a cornerstone of democracy, shaping the structure of political competition, representation, and accountability. In the case of France, it is difficult to access data describing elected representatives, though, as they are ...
Noémie Févrat +3 more
doaj +1 more source