Results 221 to 230 of about 28,581,669 (298)

Comprehensive analysis method of key risk factors in the subway operation accident by complex network and accident data. [PDF]

PLoS One
Ma S, Jiang W.
europepmc   +1 more source

Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences

Advanced Science, EarlyView.
This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu, Pan Zhang, Shangqian Wu, Hao Sun, Minwei Li, Sophia Tsoka, Zizhang Sheng, Lei Deng   +7 more
wiley   +1 more source

Hospital-Based Severe Maternal Morbidity Surveillance and Review: A Strategy for Improving Maternity Care in Maryland. [PDF]

Med Care
Creanga AA, Creanga AA, Wolfson C, Stierman E, Kramer B, Atlas R, Sheffield J, Burd I, Jones M, Zadzielski E, Aziz K.   +10 more
europepmc   +1 more source

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

Reporting patterns of suicide- and self-injury-related events involving liraglutide, semaglutide, and tirzepatide: data from the European pharmacovigilance database. [PDF]

Front Pharmacol
Scavone C, Cerasuolo M, Gaio M, Lettera N, Bernardi FF, Capuano A, Rinaldi B.   +6 more
europepmc   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Integrating Primary Health Care into Flexible Surge Capacity: Bridging the Subnational "Missing Middle" in Health Emergency Preparedness. [PDF]

Healthcare (Basel)
Khorram-Manesh A.
europepmc   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Considerations for FAIR data catalogs from DAPHNE4NFDI. [PDF]

IUCrJ
Hakim B, Dall'Antonia F, Dallmann J, Felder C, Gaur A, Görzig H, Hayen N, Hinzmann R, Kobus J, Krahl R, Murphy B, Paripsa S, Pedersen B, Raza A, Tippey K, Wetzel T, Zaft A, Unruh T, Busch S.   +18 more
europepmc   +1 more source

Fluorescent-target imaging and real-time beam diagnostics at the High Energy Photon Source. [PDF]

J Synchrotron Radiat
Zhang Q, Zhao Y, Liu Y, Gu Z, Liu S, Duan Q, Li G, Zhang Y, Zhang C.   +8 more
europepmc   +1 more source