Results 91 to 100 of about 26,204,206 (342)

BioModelKit – An Integrative Framework for Multi-Scale Biomodel-Engineering

open access: yesJournal of Integrative Bioinformatics, 2018
While high-throughput technology, advanced techniques in biochemistry and molecular biology have become increasingly powerful, the coherent interpretation of experimental results in an integrative context is still a challenge.
Blätke Mary-Ann
doaj   +1 more source

MaizeGDB update: new tools, data and interface for the maize model organism database

open access: yesNucleic Acids Res., 2015
MaizeGDB is a highly curated, community-oriented database and informatics service to researchers focused on the crop plant and model organism Zea mays ssp. mays. Although some form of the maize community database has existed over the last 25 years, there
Carson M. Andorf   +18 more
semanticscholar   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Relational Logic Database Design Model of Information System Control Project in Pt.istaka Karya [PDF]

open access: yes, 1990
Analyzing this data is to provide a clearer picture about the functions of the dataelement or attribute is being investigated. After it was done depiction of therelationship (relationship) of an existing entity such entities.
Djoko Harmantyo, DR., M.Sc Djoko Harmantyo, DR., M.Sc   +1 more
core  

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

Backup with Storage in a Database

open access: yesМоделирование и анализ информационных систем, 2016
This paper presents an overview of some technologies that are used in modern backup systems. We consider their advantages and disadvantages. Next, we consider an example of the realisation of the backup system with files store in the database. We propose
S. M. Taranin
doaj   +1 more source

A database model for object dynamics. [PDF]

open access: yes
Object-oriented database systems, Dynamic object re-classification, Object role model, Dynamic class hierarchy, Object ...
Kraamer, B., Papazoglou, M.
core   +1 more source

A relational dataflow database [PDF]

open access: yes, 1981
A model of a relational database system based on the principles of functional, data-driven computation is proposed. Relations (sets of data tuples) are represented as streams of values carried by independent tokens among operators of an unraveling ...
Bic, Lubomir
core   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu   +11 more
wiley   +1 more source

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