Results 71 to 80 of about 27,273,409 (393)
Nucleic Acids Res., 2017 The PharmMapper online tool is a web server for potential drug target identification by reversed pharmacophore matching the query compound against an in-house pharmacophore model database.
Xia Wang +8 more
semanticscholar +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Bone tumours present significant challenges for affected patients, as multimodal therapy often leads to prolonged physical limitations. This is particularly critical during childhood and adolescence, as it can negatively impact physiological development and psychosocial resilience.
Jennifer Queisser +5 more
wiley +1 more source
Improvements to PATRIC, the all-bacterial Bioinformatics Database and Analysis Resource Center
Nucleic Acids Res., 2016 The Pathosystems Resource Integration Center (PATRIC) is the bacterial Bioinformatics Resource Center (https://www.patricbrc.org). Recent changes to PATRIC include a redesign of the web interface and some new services that provide users with a platform ...
A. Wattam +27 more
semanticscholar +1 more source
An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots
FEBS Letters, EarlyView.This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino +7 more
wiley +1 more source
DB-GPT: Large Language Model Meets Database
Data Science and EngineeringLarge language models (LLMs) have shown superior performance in various areas. And LLMs have the potential to revolutionize data management by serving as the "brain" of next-generation database systems.
Xuanhe Zhou, Zhaoyan Sun, Guoliang Li
doaj +1 more source
Synthesis using speaker adaptation from speech recognition DB [PDF]
, 2010 This paper deals with the creation of multiple voices from a Hidden Markov Model based speech synthesis system (HTS). More than 150 Catalan synthetic voices were built using Hidden Markov Models (HMM) and speaker adaptation techniques.
Bonafonte Cávez, Antonio +2 more
core
From Causes for Database Queries to Repairs and Model-Based Diagnosis and Back [PDF]
, 2014 In this work we establish and investigate connections between causes for query answers in databases, database repairs wrt. denial constraints, and consistency-based diagnosis.
Bertossi, Leopoldo, Salimi, Babak
core +3 more sources
The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity
FEBS Letters, EarlyView.The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley +1 more source
, 2005 The phenomenal success of the genome sequencing projects reveals the power of completeness in revolutionizing biological science. Currently it is possible to sequence entire organisms at a time, allowing for a systemic rather than fractional view of their organization and the various genome-encoded functions.
Fidelis, K +3 more
openaire +2 more sources
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source