Results 41 to 50 of about 124,288 (293)
A Model-Driven Approach to Generate Schemas for Object-Document Mappers
IEEE Access, 2019 Many actual NoSQL systems are schemaless, that is, the structure of the data is not defined beforehand in any schema, but it is implicit in the data itself. This characteristic is very convenient when the data structure suffers frequent changes. However,
Alberto Hernandez Chillon +3 more
doaj +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Transformasi Skema Basis Data Relasional Menjadi Model Data Berorientasi Dokumen pada MongoDB
IJCCS (Indonesian Journal of Computing and Cybernetics Systems), 2016 MongoDB is a database that uses document-oriented data storage models. In fact, to migrate from a relational database to NoSQL databases such as MongoDB is not an easy matter especially if the data are extremely complex.
I Gede Winaya, Ahmad Ashari
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Modeling temporal aspects of sensor data for MongoDB NoSQL database
Journal of Big Data, 2017 Proliferation of structural, semi-structural and no-structural data, has challenged the scalability, flexibility and processability of the traditional relational database management systems (RDBMS).
Nadeem Qaisar Mehmood +2 more
doaj +1 more source
NETWORK MODELLING AND SEMANTIC 3D CITY MODELS: TESTING THE MATURITY OF THE UTILITY NETWORK ADE FOR CITYGML WITH A WATER NETWORK TEST CASE [PDF]
ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2018 Recent advances in semantic 3D city modelling and a demand from utility network operators for multi-utility data models integration have contributed to the emergence of an open Application Domain Extension (ADE) of the CityGML data model tailored to ...
I. Boates, G. Agugiaro, A. Nichersu
doaj +1 more source