Results 51 to 60 of about 22,995,424 (299)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Научный вестник МГТУ ГА, 2017 The development of new and modernization of existing aviation equipment specimens of different classes are accompanied and completed by the complex process of ground and flight tests. This phase of aviation equipment life cycle is implemented by means of
V. M. Vetoshkin +2 more
doaj
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Climates. Habitats. Environments. Database
The Environmentally-Engaged Artistic Practices in South, Southeast Asia and the Pacific Database aspires to provide a comprehensive and rich data source for artists, climate scientists, and policymakers on the artistic practices of artists and ...
Bauer, Ute Meta
core +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
W42 - a scalable spatial database system for holding Digital Elevation Models [PDF]
, 2009 The design of a scalable system for holding spatial data in general and digital elevation models (DEMs) in specific has to account for the characteristics of data from various application fields.
Roth, Achim +5 more
core +1 more source
Creating an Intelligent System for Bankruptcy Detection: Semantic data Analysis Integrating Graph Database and Financial Ontology [PDF]
, 2019 In this paper, we propose a novel intelligent methodology to construct a Bankruptcy Prediction Computation Model, which is aimed to execute a company’s financial status analysis accurately.
Yerashenia, N., Bolotov, A.
core +4 more sources
Perancangan Sistem Basis Data pada Klinik
ComTech, 2011 The purpose of this research is to analyze and design a database to support Clinic information needs. The methods used in this research are data collection, which uses the search data techniques that includes interviews, documentation, observation ...
Indrajani Indrajani
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source