Results 131 to 140 of about 1,088,169 (316)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
A data mining approach for estimating patient demand for health services [PDF]
Database Systems Journal, 2016 The ability to better forecast demand for health services is a critical element to maintaining a stable quality of care. Knowing how certain events can impact requirements, health-care service supplier can better assign available resources to more ...
Ionuţ ŢĂRANU
doaj
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Object-oriented modeling and design of database federations
We describe a logical architecture and a general semantic framework for precise specification of so-called database federations. A database federation provides for tight coupling of a collection of heterogeneous component databases into a global ...
Balsters, H.
core
DATABASE SYSTEMS FOR TOMORROW: NEW CHALLENGES AND RESEARCH AREAS
TASK Quarterly, 2003 Since the mid-80s, considerable progress has been achieved in relational database technology. The main achievements have been in high performance, high reliability and availability, scalability and development tools.
KRZYSZTOF GOCZYŁA
doaj
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
In Quest of the Bottleneck - Monitoring Parallel Database Systems
, 1997 Monitoring query processing has proven to be an effective technique to detect bottlenecks in sequential query execution systems' components. Monitoring distributed execution in parallel systems, however, is a difficult task.
Manegold, S. (Stefan) +4 more
core
, 1981 The security problem of a statistical database is to limit the use of the database so that no sequence of statistical queries is sufficient to deduce confidential or private information.
Ozsoyoglu, Gultekin, Chin, Francis Y
core +1 more source