Results 61 to 70 of about 296,784 (294)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

S-Store: Streaming Meets Transaction Processing [PDF]

, 2015
Stream processing addresses the needs of real-time applications. Transaction processing addresses the coordination and safety of short atomic computations. Heretofore, these two modes of operation existed in separate, stove-piped systems.
Aslantas, Cansu, Cetintemel, Ugur, Du, Jiang, Kraska, Tim, Madden, Samuel, Maier, David, Meehan, John, Pavlo, Andrew, Stonebraker, Michael, Tatbul, Nesime, Tufte, Kristin, Wang, Hao, Zdonik, Stan   +12 more
core   +3 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Effects of distributed database modeling on evaluation of transaction rollbacks [PDF]

Data distribution, degree of data replication, and transaction access patterns are key factors in determining the performance of distributed database systems. In order to simplify the evaluation of performance measures, database designers and researchers
Mukkamala, Ravi
core   +4 more sources

Transaction Costs and Organizational Competences: Explaining the Governance Structure for Manufacturing Stage

Journal of Technology Management & Innovation, 2012
This article deals with the influence of transaction costs and organizational competences on the choice of governance structure for manufacturing stage in a productive system.
Antonio Carlos Lima Nogueira, Walter Bataglia   +1 more
doaj   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Improving transaction abort rates without compromising throughput through judicious scheduling [PDF]

, 2013
Althought optimistic concurrency control protocols have increasingly been used in distributed database management systems, they imply a trade-of between the number of transactions that can be executed concurrently, hence, the peak throughput, and ...
Nunes, Ana, Pereira, José
core   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Discovering Imperceptible Associations Based on Interestingness: A Utility-Oriented Data Mining

Data Science Journal, 2010
This article proposes an innovative utility sentient approach for the mining of interesting association patterns from transaction databases. First, frequent patterns are discovered from the transaction database using the FP-Growth algorithm.
S Shankar, T Purusothaman
doaj   +1 more source

A Survey of Languages for Specifying Dynamics: A Knowledge Engineering Perspective [PDF]

, 2000
A number of formal specification languages for knowledge-based systems has been developed. Characteristics for knowledge-based systems are a complex knowledge base and an inference engine which uses this knowledge to solve a given problem.
Engelfriet, Joeri, Fensel, Dieter, van Eck, Pascal, van Harmelen, Frank, Venema, Yde, Willems, M., Willems, Mark   +6 more
core   +7 more sources