Results 121 to 130 of about 265,175 (324)
Indonesian Journal of Research in Islamic StudiesBackground: In Muslim-majority contexts, religious and cultural values significantly shape adolescents' emotional development, particularly in dating-related behaviors, attachment styles, and emotion regulation. Objective: The research aims to examine how dating status influences attachment styles and emotion regulation strategies among Muslim ...
Muhammad Hisyam Syafii +2 more
openaire +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Indicators for measuring and reporting corporate nature-related impacts, dependencies, and risks
Environmental and Sustainability IndicatorsBusinesses are embedded within nature. Their supply chains, operations, and products fundamentally depend on and impact nature. These impacts and dependencies can give rise to nature-related risks (as well as related opportunities).
Greg S. Smith +3 more
doaj +1 more source
Sleepy Hollow, Village of and Municipal Employee Unit, United Federation of Police Officers [PDF]
, 2011 In the matter of the fact-finding between the Village of Sleepy Hollow, employer, and the United Federation of Police Officers, Municipal Employee Unit, union. PERB case no. M2009-266. Before: Peter A.
Korn, Peter A
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Infinite cographs and chain complete N-free posets
, 2018 We give a necessary and sufficient condition for a $P_4$-free graph to be a cograph. This allows us to obtain a simple proof of the fact that finite $P_4$-free graphs are finite cographs. We also prove that chain complete posets whose comparability graph
Zaguia, Imed
core
Leverage Existing Efforts or Use a Centralized Approach? [PDF]
, 2010 Compares two strategies for a standardized community-wide approach to collecting and reporting data on patients' experience of ambulatory care: building on existing surveys with a common set of core questions or one survey administered by a single ...
core