Results 111 to 120 of about 966,720 (305)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
A Hiatus in the Cutting of Buddhist Caves in the Western Deccan
Ancient Asia, 2010 This article places the expansion of Buddhist monasteries in the Western Deccan in its wider context, examining how social, political and economic forces might have impacted on the tempo of Buddhist cave cutting.
Gethin Rees
doaj +1 more source
Breaking the Cycle: An Examination of Environmental, Cognitive, and Emotional Factors of Intimate Partner Violence Victim [PDF]
, 2016 Recently, intimate partner violence (IPV) has gained considerable attention as a significant social and public health problem affecting not only adults but also adolescents. Based on Bandura’s social learning theory, considerable research has supported a
Davila, America
core +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Scottish Archaeological Internet ReportsArchaeological excavations conducted in 2017 at Grantown Road, Forres form the final phase of works on a residential development that began in 2002. The earlier works examined an area of more than 70ha and confirmed the presence of an extensive Iron Age settlement represented by ring-ditch, ring-groove, and post-ring structures, in association with ...
openaire +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Dating Business Cycle Turning Points [PDF]
This paper discusses formal quantitative algorithms that can be used to identify business cycle turning points. An intuitive, graphical derivation of these algorithms is presented along with a description of how they can be implemented making very ...
James D. Hamilton, Marcelle Chauvet
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