Results 81 to 90 of about 58,177 (265)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

New insights on angiosperm crown age based on Bayesian node dating and skyline fossilized birth-death approaches

Nature Communications
Despite considerable work in recent years, pinpointing the time when angiosperms originated has been challenging. However, the rapid development of molecular clock methodology has provided new tools to resolve this conundrum.
Xiaoya Ma, Chi Zhang, Lingxiao Yang, S. Blair Hedges, Bojian Zhong   +4 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

DO ADOLESCENTS USE DATING APPS TO FIND SEXUAL PARTNERS? A STUDY OF MOTIVATION OF DATING APPS USE AMONG ADOLESCENTS IN INDONESIA

The Indonesian Journal of Public Health
Introduction: The existence of dating apps as a form of technological advancement has given individuals new ways to search for a romantic partner. Twenty-five percent of newlywed couples met through dating apps, while 40% of unmarried individuals were ...
Andhika Ajie Baskoro, Sari Kistiana, Desy Nuri Fajarningtyas, Evalina Franciska Hutasoit   +3 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

El consum dels Date Shows

, 2017
En aquest treball s'intenten trobar les raons per les quals els espectadors veuen els date shows, a més de saber els factors positius que aquests programes tenen per atreure a la gent. També s'analitza el fenomen de "First Dates" com a recent estrena del gènere i l'impacte que aquest tipus de programes tenen a nivell internacional.
Jamois i Ruiz, Irina, Universitat Autònoma de Barcelona. Facultat de Ciències de la Comunicació   +1 more
openaire   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Holocene Provenance Identification and Climate Control of Indus Basin By Using Radiogenic Techniques and Clay Mineralogy [PDF]

International Journal of Economic and Environment Geology, 2011
Two commonly used isotopic methods (Zircon U-Pb dating and K-feldspar Pb dating) were employed for the Holocene provenance identification within the Indus basin.
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doaj