Results 51 to 60 of about 711,478 (286)

JWST Insight into a Lensed HST-dark Galaxy and Its Quiescent Companion at z = 2.58

The Astrophysical Journal Letters, 2023
Using the novel James Webb Space Telescope (JWST)/NIRCam observations in the A2744 field, we present a first spatially resolved overview of a Hubble Space Telescope (HST)-dark galaxy, spectroscopically confirmed at z = 2.58 with magnification μ ≈ 1.9 ...
Vasily Kokorev, Shuowen Jin, Georgios E. Magdis, Karina I. Caputi, Francesco Valentino, Pratika Dayal, Maxime Trebitsch, Gabriel Brammer, Seiji Fujimoto, Franz Bauer, Edoardo Iani, Kotaro Kohno, David Blánquez Sesé, Carlos Gómez-Guijarro, Pierluigi Rinaldi, Rafael Navarro-Carrera   +15 more
doaj   +1 more source

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

SEA FOG DETECTION BASED ON DYNAMIC THRESHOLD ALGORITHM AT DAWN AND DUSK TIME [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2019
Dawn and dusk time is the high frequency period of sea fog occurrence, which is very important for all-day sea fog remote sensing detection. Most polar orbit satellites are limited by time resolution and transit time, and can not detect sea fog at dawn ...
J. H. Wan, L. Jiang, Y. F. Xiao, H. Sheng   +3 more
doaj   +1 more source

ITGB1 Regulates Triple‐Negative Breast Cancer Development by Modulating the Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumorigenesis and metastasis are frequently attributed to the intricate interplay between cancer cells and the tumor microenvironment (TME). Comprehending the mechanisms and key regulators of cancer‐immune crosstalk in the TME is imperative for developing efficacious immunotherapy.
Nuozi Song, Siqi Chen, Lei Wang, Jessica Dang, Xu Cao, Stephanie Singh, Lu Yang, Jinhui Wang, Steven T. Rosen, Yingyu Wang, Chun‐Wei D. Chen, Cheng Zhang, Mingye Feng   +12 more
wiley   +1 more source

Influence of CO2 retention mechanism storage in Alberta tight oil and gas reservoirs at Western Canadian Sedimentary Basin, Canada: hysteresis modeling and appraisal

Journal of Petroleum Exploration and Production Technology, 2020
Rapid combustion of fossil fuels in huge quantities resulted in the enormous release of CO2 in the atmosphere. Subsequently, leading to the greenhouse gas effect and climate change and contemporarily, quest and usage of fossil fuels has increased ...
Perumal Rajkumar, Venkat Pranesh, Ramadoss Kesavakumar   +2 more
doaj   +1 more source

Unfettered hope: a call to faithful living in an affluent society [PDF]

, 2005
Title: Unfettered hope: a call to faithful living in an affluent society. Author: Dawn, Marva J Unfettered hope xxii, 216 p.
Weigel, Arnold D.
core   +1 more source

KDM4A Erases the H3R17me2a Mark, Facilitating Chromosome Condensation

Advanced Science, EarlyView.
This study reveals a reversible histone modification switch governing chromosome condensation during mitosis. PKCα‐activated KDM4A removes H3R17me2a, permitting Suv39h1‐driven H3K9me3 deposition. This epigenetic transition recruits the chromosomal passenger complex and triggers Aurora B‐dependent H3S10 phosphorylation, coordinating chromatin remodeling
Yena Cho, Jee Won Hwang, Gyu Hwan Hyun, Sangkyu Lee, Dae‐Geun Song, Su‐Nam Kim, Yong Kee Kim   +6 more
wiley   +1 more source

First mineralogical maps of 4 Vesta [PDF]

, 2012
Before Dawn arrived at 4 Vesta only very low spatial resolution (~50 km) albedo and color maps were available from HST data. Also ground-based color and spectroscopic data were utilized as a first attempt to map Vesta’s mineralogical diversity [1-4]. The
Ammannito, E., Barucci, M. A., Blewett, D., Capaccioni, F., Capria, M. T., Combe, J. P., De Sanctis, Maria Cristina, Denevi, B., Frigen, A., Jaumann, Ralf, Keller, H. U., Le Corre, L., Li, J. Y., Marchi, S., McCord, T. B., McFadden, L.A., McSween, H.Y., Nathues, A., Palomba, E., Pieters, Carle M., Raymond, C.A., Reddy, V., Russell, C.T., Stephan, K., Sunshine, J.M., Toplis, M., Tosi, Nicola, Yingst, A., Zambon, A.   +28 more
core  

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source