Results 71 to 80 of about 9,319,518 (313)

Themes and time use by participants in general team meetings at a psychiatric day hospital Temas y utilización del tiempo por los participantes de reuniones del equipo general en un hospital día psiquiátrico Temas e utilização do tempo pelos participantes de reuniões de equipe geral em um hospital-dia psiquiátrico

Revista Latino-Americana de Enfermagem, 2007
This naturalistic study was realized through observation and aimed to characterize general staff meetings held at a day hospital regarding theme and the professionals' participation in the use of time.
Edson Arthur Scherer, Maria Auxiliadora Campos, Zeyne Alves Pires Scherer   +2 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The association of cognitive behavioral intervention with caregiver burden and quality of life among family caregivers of cancer recurrence patients

Frontiers in Psychiatry
ObjectiveThis study aimed to evaluate the immediate and 3-month follow-up associations of cognitive behavioral intervention (CBI) on caregiver burden and quality of life (QOL) among family caregivers of patients with recurrent cancer.MethodsA quasi ...
Zhan Zhang, Han Zhou, Xiaoyu Guo, Bo Zheng   +3 more
doaj   +1 more source

Telephone triage for management of same-day consultation requests in general practice (the ESTEEM trial): a cluster-randomised controlled trial and cost-consequence analysis [PDF]

, 2014
BACKGROUND: Telephone triage is increasingly used to manage workload in primary care; however, supporting evidence for this approach is scarce. We aimed to assess the effectiveness and cost consequences of general practitioner-(GP)-led and nurse-led ...
Lattimer, V, Richards, David A, Richards, SH, Warren, Fiona C., Kandiyali, R, Kandiyali, Rebecca, Campbell, John L, Green, C, Salisbury, Chris, Varley, A, Richards, DA, Murdoch, J, Taylor, RS, Varley, Anna, Green, Colin, Warren, Fiona C, Warren, FC, Britten, N, Britten, Nicky, Richards, Dave A., Chaplin, Katherine, Holt, TA, Taylor, Rod S, Richards, Suzanne H, Murdoch, Jamie, Bowyer, V., Roscoe, J, Fletcher, Emily, Richards, David A., Richards, Suzanne H., Chaplin, K, Holt, Tim A, Bowyer, Vicky, Fletcher, E, Taylor, Rod, Lattimer, Valerie Ann, Lattimer, Valerie, Taylor, Rod S., Campbell, JL, Bowyer, V, Campbell, John L., Holt, Tim A., Salisbury, C, Calitri, R, Calitri, Raff, Roscoe, Julia, Kandiyali, Rebecca S, N, Britten, E, Fletcher, K, Chaplin, R, Calitri, Murdoch, Jamie; id_orcid, V, Bowyer, JL, Campbell, TA, Holt, C, Salisbury, R, Kandiyali, V, Lattimer, RS, Taylor, C, Green, DA, Richards, SH, Richards   +61 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Sowing in the autumn season : exploring benefits of green care farms for dementia patients [PDF]

, 2009
In the Netherlands an increasing number of farms combine agricultural production with care services for people with care needs. It is generally believed that these green care farms (GCFs) have beneficial effects on the health status of a diversity of ...
Bruin, S.R., de
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source