Results 101 to 110 of about 1,188 (237)

Continuous Subcutaneous Foslevodopa/Foscarbidopa in Advanced Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Continuous subcutaneous foslevodopa/foscarbidopa (LDp/CDp) provides 24‐h delivery of levodopa‐carbidopa prodrugs for advanced Parkinson's disease. Real‐world 1‐year European data remain limited. Objectives To characterize 1‐year changes in motor, non‐motor, autonomic, quality‐of‐life and sleep outcomes, and in concomitant therapy ...
Mario Hero, Nadja Grozdanić, Romana Brnić Andrić, Eliša Papić, Olivio Perković, Vladimira Vuletić   +5 more
wiley   +1 more source

Enhancing Daylight and Energy Efficiency in Hot Climate Regions with a Perforated Shading System Using a Hybrid Approach Considering Different Case Studies

Buildings
Direct sunlight causes glare and reduces indoor daylight quality, making shading systems essential. This study proposes and validates a perforated shading screen (PSS) to enhance daylighting and energy efficiency. A hybrid approach integrating parametric
Basma Gaber, Changhong Zhan, Xueying Han, Mohamed Omar, Guanghao Li   +4 more
doaj   +1 more source

Progression of Motor and Cognitive Functions in Isolated REM Sleep Behavior Disorder: A 7‐Year Prospective Matched Cohort Study

Movement Disorders, EarlyView.
Abstract Background Although clinical markers (eg, motor and cognitive impairment) in isolated rapid eye movement sleep behavior disorder (iRBD) are associated with faster phenoconversion, their longitudinal trajectory patterns (linear or nonlinear) remain unclear.
Li Zhou, Yaping Liu, Bei Huang, Jing Wang, Shi Tang, Yuhua Yang, Siyi Gong, Steven W.H. Chau, Joey W.Y. Chan, Mandy W.M. Yu, Jessie C.C. Tsang, Shirley Xin Li, Siu Ping Lam, Vincent C.T. Mok, Karen K.Y. Ma, Anne Y.Y. Chan, Jihui Zhang, Yun Kwok Wing   +17 more
wiley   +1 more source

Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms

Medicinal Research Reviews, EarlyView.
ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino, Manuela Bartolini, Rudolf Andrys, Kamil Musilek   +3 more
wiley   +1 more source

Daylight autonomy and facade design : From research to practice for the Stockholm SEB Bank head office

, 2014
QC ...
Lundgren, Marja, Zinnecker, Max, Runberger, Jonas, Grahn, Sara, Dubois, Marie-Claude   +4 more
openaire   +1 more source

Mirabegron and Intradetrusor Onabotulinumtoxina for Overactive Bladder in Parkinson's Disease: A Systematic Review and Meta‐Analysis

Neurourology and Urodynamics, EarlyView.
ABSTRACT Objective To synthesize the evidence on the efficacy and safety of mirabegron and intradetrusor onabotulinumtoxinA (BoNT‐A) as separate interventions for overactive bladder (OAB) in Parkinson's disease (PD). Methods A systematic review and meta‐analysis with parallel synthesis of two distinct interventions was conducted of randomized and ...
Hussain Arshad, Raiyana Nuha, Shehab Khashaba, David Gillatt, Simon J. G. Lewis   +4 more
wiley   +1 more source

Beyond Joint Hypermobility: Investigating Bladder Dysfunction in Hypermobile Ehlers‐Danlos Syndrome

Neurourology and Urodynamics, EarlyView.
ABSTRACT Introduction and Objectives Hypermobile Ehlers‐Danlos Syndrome (hEDS) is the most common subtype of Ehlers‐Danlos Syndrome, a group of connective tissue disorders caused by collagen abnormalities. While musculoskeletal features of hEDS are well characterized, its impact on visceral organs, including the bladder, remains underexplored.
Marium Ansari, Mallory Pine, Viktoriya Sapkalova, Emily Chan Brodowsky, Charles R. Powell, Ramzy T. Burns   +5 more
wiley   +1 more source

Daylight Optimization - A Parametric Study of Atrium Design : Early Stage Design Guidelines of Atria for Optimization of Daylight Autonomy

, 2014
This thesis investigates the design of atria for daylighting in large scale buildings. Athree dimensional test building with a central atrium was constructed and various parameters of the atrium altered. The impact of these changes was studied through computer simulations of annual daylight distribution by implementing state of theart software ...
openaire   +1 more source

Comparative Analysis of Daylight and Visual Quality Across School Plan Typologies: A Spatial Layout Perspective

Journal of Daylighting
Designing daylight-based spaces has gained increasing attention due to its numerous benefits and alignment with global sustainability standards. However, limited research has focused on how architectural layouts affect daylight distribution and visual ...
Seyed Hossein Neshat Safavi, Elham Shokri, Behzad Vasigh, Saeed Banihashemi, Akram Esfandiari   +4 more
doaj   +1 more source

Imaging patterns and genetic associations of brain atrophy across distinct symptom stages in Parkinson's disease

Neuroprotection, EarlyView.
Early disease stages showed limited cortical atrophy and enrichment of synaptic and calcium signaling pathways, whereas advanced stages demonstrated widespread cortical degeneration associated with immune activation and extracellular matrix remodeling.
Yi Ji, Liujia Lu, Kaidong Chen, Ruixuan Zhang, Yao Lu, Yachen Shi, Xiangming Fang   +6 more
wiley   +1 more source