Results 161 to 170 of about 154,159 (310)

Hypnotic doses of fazamorexant induced less impairment on balance and cognition than zolpidem in healthy younger and elderly individualse

British Journal of Clinical Pharmacology, EarlyView.
Aims Fazamorexant is a dual orexin receptor antagonist being developed for the treatment of insomnia. This study aims to determine the dose‐exposure‐response relationship of single‐dose fazamorexant vs. zolpidem in young adult and elderly healthy Chinese volunteers. Methods This single‐centre, randomized, double‐blind, double‐dummy, placebo‐ and active‐
Chen Xia, Huang Xingxing, Jin Lu, Wang Ruwei   +3 more
wiley   +1 more source

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

British Journal of Clinical Pharmacology, EarlyView.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić, Patrick Eustaquio, Elvira Meni Maria Gkrinia, Ivana Stević, Eugen Javor, Yun Wah Lam, Slobodan Janković, Dinko Vitezić   +7 more
wiley   +1 more source

Operational stability of mixed Sn–Pb perovskite solar cells: Mechanisms, mitigation strategies, and perspectives

Bulletin of the Korean Chemical Society, EarlyView.
This review consolidates mechanisms and solutions for mixed Sn–Pb perovskite solar cells. It identifies Sn2+ oxidation, iodine generation, and interfacial defects as primary instabilities. It discusses progress in additives, interface passivation, alternative hole transport layers, and solvent engineering as well as future directions for achieving long‐
Lei Chen, Kai Zhu
wiley   +1 more source

The myth of the metabolic baseline: sleep–wake cycles undermine a foundational assumption in organismal biology

Biological Reviews, EarlyView.
ABSTRACT Basal and standard metabolic rate (BMR and SMR) are cornerstones of physiological ecology and are assumed to be relatively fixed intrinsic properties of organisms that represent the minimum energy required to sustain life. However, this assumption is conceptually flawed. Many core maintenance processes underlying SMR are temporally partitioned
Helena Norman, Daphne Cortese, Amelia Munson, Jan Lindström, Shaun S. Killen   +4 more
wiley   +1 more source

Host, vector, and parasite dynamics: exploring intrinsic and extrinsic factors shaping tick‐borne filarial nematode transmission

Biological Reviews, EarlyView.
ABSTRACT Tick‐borne filarial nematodes are a complex and understudied group of parasites that rely on ticks for transmission in vertebrates. This review examines how intrinsic and extrinsic factors may influence the successful transmission of filarial nematodes in tick vectors, drawing insights from extensively studied haematophagous dipteran vector ...
Oluwaseun D. Ajileye, Gabriel L. Hamer, Sarah A. Hamer, Guilherme G. Verocai, Jessica E. Light   +4 more
wiley   +1 more source

The Use of Renewable Energy in Prominent City Buildings: A Diffusion Study on Top European Football Organizations

Business Strategy and the Environment, EarlyView.
ABSTRACT The present study applied the diffusion of innovation theory to investigate the rate of diffusion of renewable energy sources used by Europe's top professional football stadiums and the relationship with carbon neutrality. A discrete diffusion model estimated the diffusion of renewable energy to saturation, and a multivariate logistic ...
Chad S. Seifried, Liz Wanless, Timothy Kellison   +2 more
wiley   +1 more source

Daylighting and Energy Performance of PVSDs;

Scientific Research Journal, 2020
Mai A. Marzouk, Mostafa Atwa
openaire   +1 more source

An All‐in‐One Lignin‐Based Artificial Thylakoid Nanovesicle Via In‐Situ Confined Growth Strategy for High‐Efficient and Selectivity CO2 Photoreduction

Carbon Energy, EarlyView.
The low light/CO2 capture and slow dynamic transfer of photogenerated electrons hamper photocatalysts’ high activity and selectivity. Inspired by the chloroplast's photosynthesis mechanism, an all‐in‐one lignin‐based artificial thylakoid nanovesicle (AiO‐L‐ATN) is constructed using a confined growth strategy of lignin molecules. The performance of such
Hang Wang, Ganmao Su, Xianxian Lin, Yan Qing, Yiqiang Wu, Fuxiang Chu, Fuquan Xiong   +6 more
wiley   +1 more source

Photoinduced Electron Transfer (PET) as Key to Accelerate the Cycloreversion Reaction of Arylquadricyclanes

Chemistry – A European Journal, EarlyView.
It is demonstrated that the photoinduced cycloreversion of a methoxynaphthylquadricyclane in the presence of suitable photocatalysts gives quantitatively the corresponding norbornadiene. As this photochromic norbornadiene‐quadricyclane cycle has favorable properties for light energy conversion, this method provides a useful tool for the targeted ...
Julian Felix Maria Hebborn, Heiko Ihmels, Marco Löcker, Thomas Paululat, Robin Schulte   +4 more
wiley   +1 more source

Are you always working in the dark? The impact of limited daylight exposure on radiologists' health. [PDF]

Insights Imaging
Landsmann A, Rovetto C, Knöpfli F, Kubik-Huch RA.   +3 more
europepmc   +1 more source