Results 51 to 60 of about 74,403 (250)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

The Spectral Types of White Dwarfs in Messier 4

open access: yes, 2009
We present the spectra of 24 white dwarfs in the direction of the globular cluster Messier 4 obtained with the Keck/LRIS and Gemini/GMOS spectrographs.
Bergeron   +21 more
core   +1 more source

The Physics of Crystallization from Globular Cluster White Dwarf Stars in NGC 6397 [PDF]

open access: yes, 2009
We explore the physics of crystallization in the deep interiors of white dwarf stars using the color-magnitude diagram and luminosity function constructed from proper motion cleaned Hubble Space Telescope photometry of the globular cluster NGC 6397.
Abrikosov   +26 more
core   +3 more sources

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

open access: yesFEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru   +6 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

A Census of White Dwarfs Within 40 Parsecs of the Sun

open access: yes, 2010
Our aim is to compile a catalog of white dwarfs within 40 parsecs of the Sun, in which newly discovered objects would significantly increase the completeness of the current census.
Bergeron, P.   +2 more
core   +1 more source

A Theoretical Investigation of He i Line Profiles for the Spectroscopic Analysis of DB White Dwarfs

open access: yesThe Astrophysical Journal
We present a comprehensive investigation of He i line profile calculations used in the spectroscopic analyses of DB white dwarfs. Our study includes an in-depth photometric and spectroscopic analysis of all DB white dwarfs in Data Release 17 of the Sloan
Patrick Tremblay   +2 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

open access: yesFEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner   +7 more
wiley   +1 more source

Hot DAVs : a probable new class of pulsating white dwarf stars [PDF]

open access: yes, 2013
We have discovered a pulsating DA white dwarf at the lower end of the temperature range 45 000–30 000 K where a few helium atmosphere white dwarfs are known. There are now three such pulsators known, suggesting that a new class of theoretically predicted
B. T. Gänsicke   +42 more
core   +2 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

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