Results 91 to 100 of about 40,050 (263)

Polarity on Demand: Nucleophilic, Electrophilic, and Ambiphilic Reactivity at a 9,10‐Dihydro‐9,10‐Disilaanthracene Platform

Chemistry – A European Journal, EarlyView.
A 9,10‐dihydro‐9,10‐disilaanthracene platform was efficiently synthesized and features intrinsically electrophilic Si sites. Upon stepwise reductive Si─H bond cleavage, these Si sites are converted into nucleophilic centers. This controlled polarity switching also enables ambiphilic reactivity within a homo‐heteroelement framework.
Moritz Schmidt, Alexander Virovets, Eugenia Peresypkina, Hans‐Wolfram Lerner, Matthias Wagner   +4 more
wiley   +1 more source

Assessment of Abuse Potential‐Related Effects of Oral Dried Kratom Leaf Powder in Healthy Normal Participants Following Single and Multiple Daily Doses

Drug Testing and Analysis, EarlyView.
In a randomized, double‐blind, placebo‐controlled study of oral dried kratom leaf powder in healthy kratom‐naive adults, no participants met the clinically meaningful opioid withdrawal threshold; abuse‐related treatment‐emergent adverse events occurred more frequently at higher doses but were generally mild and resolved without sequelae; and no serious
Marion Coe, Marilyn Huestis, Daniel Wang, Thomas Hudzik, John Bothmer, Jack Henningfield   +5 more
wiley   +1 more source

A cadaveric morphometric analysis of the deep brachial artery

Folia Morphologica
BACKGROUND: The primary aim of this study was to conduct precise measurements of the deep brachial artery (DBA) on cadaveric upper-limb specimens. A comprehensive understanding of DBA anatomy and its variations is essential for reconstructive procedures ...
Wojciech Przybycień, Patryk Ostrowski, Martyna Dziedzic, Ewa Mizia, Michał Korman, Magdalena Martyka-Łaś, Filip Staszewski, Andrzej Żytkowski, Mateusz Koziej, Jerzy A. Walocha   +9 more
doaj   +1 more source

Ranking of antiseizure medications in a panel of focal seizure models predicts their comparative efficacy in clinical add‐on trials in drug‐resistant focal epilepsy

Epilepsia, EarlyView.
Abstract Objective Most antiseizure medications (ASMs) have been discovered by testing in animal models, which are generally thought to predict antiseizure activity in patients. However, it is not known whether any of these models (or a combination of models) can predict whether a novel ASM exhibits higher clinical efficacy in focal drug‐resistant ...
Wolfgang Löscher, Pavel Klein
wiley   +1 more source

Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges

Epilepsia Open, EarlyView.
Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus, Cesar Santana‐Gomez, Ruby G. Escalante, Dominique Duncan, Pedro F. Viana, Giulia Sofia Cereda, Naoto Kuroda, Aristea S. Galanopoulou   +7 more
wiley   +1 more source

Reverse evolution of fluorine and side chains in bisisoindigo‐based copolymers enabling electron mobility exceeding 7 cm2·V−1·s−1

FlexMat, EarlyView.
Abstract We report the design and synthesis of a series of bisisoindigo‐based donor–acceptor (D–A) copolymers, P4F18, P4F10, P2F18, and P2F10. By reverse evolution of fluorine substitution and side‐chain structure, we effectively tuned the frontier molecular orbital energy levels, intermolecular interactions, molecular self‐assembly, and thus charge ...
Keli Shi, Chang Cui, Qianqian Zhao, Jianping Chen, Weifeng Zhang, Jiadi Chen, Qian Che, Yunchao Zhang, Youjia Li, Zhihui Chen, Liping Wang, Gui Yu   +11 more
wiley   +1 more source

Early‐Stage Glottic Squamous Cell Carcinoma: A Nationwide Analysis on Incidence, Survival, Recurrences, and Laryngectomies After Radiotherapy in the Netherlands (2015–2021)

Head &Neck, EarlyView.
ABSTRACT Objective Growing interest in new radiotherapy strategies for early‐stage glottic cancer highlights the importance of reviewing current treatment outcomes. This nationwide study presents the incidence, survival, recurrences, and laryngectomies for these patients.
Sabine M. L. Linden, Boukje A. C. van Dijk, Marielle E. P. Philippens, Gerben E. Breimer, Remco de Bree, Johannes A. Rijken, Mischa de Ridder   +6 more
wiley   +1 more source

Improving Quality of Research on Herbals and its Reporting

Ancient Science of Life, 2016
DBA Narayana
doaj   +1 more source

Safe Omission of Postoperative Neck Irradiation in Selected pN0 Patients With Locally Advanced Oral Cavity Squamous Cell Carcinoma

Head &Neck, EarlyView.
ABSTRACT Background Postoperative radiotherapy is the standard treatment for locally advanced oral squamous cell carcinoma (OSCC); however, the indication for neck irradiation (NI) in pN0 patients remains debatable. We evaluated whether the omission of NI compromises outcomes in pT3–T4 pN0 patients treated with adequate neck dissection (ND).
Mathilde Mirallié, Anouchka Modesto, Marie Pajiep, Sébastien Vergez, Jérôme Sarini, Lucie Piram, Céline Dalmasso, Benjamin Vairel, Emilien Chabrillac, Agnès Dupret‐Bories   +9 more
wiley   +1 more source

A Compact Circularly Polarized Luminescence Emitter–Chirality of a [2.2]‐Paracyclophane Macrocycle

Helvetica Chimica Acta, EarlyView.
A comprehensive chiroptical study of a [2.2]paracyclophane‐based (PCP) macrocycle and its synthetic open precursor reveals intense chiroptical responses. Featuring strong electric circular dichroism (ECD) bands and high luminescence dissymmetry factors (|glum|≈ 10−2), this scaffold serves as an ideal model for investigating chirality and developing ...
Salome L. Heim, Adriano D'Addio, Olaf Fuhr, Dieter Fenske, Marcel Mayor   +4 more
wiley   +1 more source