Results 151 to 160 of about 162,662 (298)

Toxicokinetic modelling of the synthetic cannabinoid 5F‐MDMB‐P7AICA and its main metabolite in pigs following pulmonary administration

British Journal of Clinical Pharmacology, EarlyView.
Aims Since their emergence on the drug market, synthetic cannabinoids (SC) are still gaining increasing importance in forensic toxicology. The representatives of the so‐called new psychoactive substances have in common that they have not undergone preclinical safety studies. Hence, knowledge on toxicokinetic (TK) data is sparse.
Adrian A. Doerr, Christiane Dings, Omar Zaher, Frederike Nordmeier, Nadja Walle, Matthias W. Laschke, Michael D. Menger, Peter H. Schmidt, Markus R. Meyer, Thorsten Lehr, Nadine Schaefer   +10 more
wiley   +1 more source

Noise in the Intensive Care Unit: A Narrative Review of Its Characteristics, Clinical Impact, and Reduction Strategies. [PDF]

Crit Care Res Pract
Vrettou CS, Koliotsis PT, Golemati S, Mastorakis G, Karaviti V, Mavromati S, Tagara M, Papadopoulou MP, Dimopoulou I.   +8 more
europepmc   +1 more source

Pharmacological treatment with a GABA(A) receptor modulator and a selective serotonin reuptake inhibitor as a mitigation strategy against aircraft noise‐induced cardiovascular and neuronal damage

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Noise pollution, particularly by aircraft, is a significant risk factor for cardiovascular disease. Aircraft noise activates stress response pathways in the brain, via the amygdala, the sympathetic nervous system and the hypothalamic–pituitary–adrenal axis.
Ivana Kuntić, Marin Kuntić, Jiayin Zheng, Leonardo Nardi, Matthias Oelze, Arijan Valar, Dominika Mihaliková, Lea Strohm, Hans‐Georg Buchholz, Nicole Bausbacher, Simon Lange, Henning Ubbens, Qi Tang, Liyu Zhang, Guilherme Horta, Paul Stamm, Omar Hahad, Axel Methner, Sebastian Steven, Huige Li, Mathias Schreckenberger, Dilja Krueger‐Burg, Adrian Gericke, Michael J. Schmeisser, Thomas Münzel, Andreas Daiber   +25 more
wiley   +1 more source

Novel behavioral tasks for the measurement of social motivation in mice: a comparison across strains. [PDF]

Front Behav Neurosci
Wells C, Huddleston KP, Brown S, Razzaq F, Chick D, Rogers TD.   +5 more
europepmc   +1 more source

Triple‐Mutated HSV‐1 Expressing Soluble B7‐1 Plus CTLA‐4 Blockade Suppresses Lymph Node Metastasis in Tongue Cancer

Cancer Science, EarlyView.
In murine tongue cancer models, T‐mB7‐1, a triple‐mutated oncolytic herpes simplex virus type 1 (HSV‐1) engineered to express soluble B7‐1, suppresses cervical lymph node metastasis and improves survival, addressing a major prognostic determinant in oral squamous cell carcinoma (OSCC).
Akinari Sugauchi, Toshihiro Uchihashi, Hirotaka Ito, Miwako Iwai, Yuzuri Tsurumaki Sato, Kyoko Kurioka, Sena Zeynep Usta, Minoru Tanaka, Mikihiko Kogo, Susumu Tanaka, Hiroshi Fukuhara, Tomoki Todo   +11 more
wiley   +1 more source

Comparative Multi-Omics Analysis of the Iridocorneal Angle Identifies an Immune-Fibrotic Profile in the DBA/2J Glaucoma Mouse Model. [PDF]

Mol Cell Proteomics
Shim MS, Grimsrud A, Desikan V, Sung MS, Liton PB.   +4 more
europepmc   +1 more source

Is Obesity Associated With Dental Caries in Primary Dentition? Findings From a Birth Cohort in Southern Brazil

Community Dentistry and Oral Epidemiology, EarlyView.
ABSTRACT Objectives Nutritional disorders and dental caries share common risk factors, including diet and socioeconomic position, but the association between these two conditions remains unclear. The aim of this study was to investigate the potential association between overweight/obesity and the occurrence of dental caries in primary dentition ...
Yorrana Martins Corrêa, Cinthia Fonseca Araujo, Mariana Silveira Echeverria, Andréa Dâmaso Bertoldi, Geert J. M. G. van der Heijden, Flávio Fernando Demarco, Helena Silveira Schuch   +6 more
wiley   +1 more source

Impact Absorption Power of Polyolefin Fused Filament Fabrication 3D‐Printed Sports Mouthguards: In Vitro Study

Dental Traumatology, Volume 41, Issue 2, Page 213-223, April 2025.
ABSTRACT Background/Aim This study aims to evaluate and compare the impact absorption capacities of thermoformed ethylene vinyl acetate (EVA) mouthguards and 3D‐printed polyolefin mouthguards used in sports dentistry applications. The objective is to determine whether 3D‐printed polyolefin mouthguards offer superior impact toughness compared to ...
Leonardo Mohamad Nassani, Samuel Storts, Irina Novopoltseva, Lauren Ann Place, Matthew Fogarty, Pete Schupska   +5 more
wiley   +1 more source

Photoinduced Ring-Opening Polymerization of N-Carboxyanhydrides for the Preparation of Cross-Linked Polypeptide Gels. [PDF]

Angew Chem Int Ed Engl
Kočman A, Pahovnik D, Žagar E, Utroša P.   +3 more
europepmc   +1 more source

Quantitative analysis of DNA‐GATA1 binding alterations linked to hematopoietic disorders

The FEBS Journal, EarlyView.
Native holdup allows the quantitative determination of affinities between full‐length transcription factors and DNA. Mutations in either the protein or the DNA can modulate binding strength, which can be precisely quantified using this approach. Applied to GATA1, it revealed mutations that alter DNA binding.
Boglarka Zambo, Bastien Morlet, Luc Negroni, Orsolya Mózner, Balázs Sarkadi, Gilles Travé, Gergo Gogl   +6 more
wiley   +1 more source