Results 181 to 190 of about 40,050 (263)

Ultrafast Electron Dynamics of a Ferrocene-Based Butadiyne-Bridged Complex. [PDF]

open access: yesJ Phys Chem A
Mendis KC   +7 more
europepmc   +1 more source

Pd‐Catalyzed Cyclotrimerization and Cycloaddition of 5,6‐Didehydrobenzo[8]annulenes (BenzoCOTynes): Formation of Nonplanar Tri[8]annulenes and Diels–Alder Cycloadducts

open access: yesEuropean Journal of Organic Chemistry, Volume 29, Issue 23, 16 June 2026.
A Pd(0)‐catalyzed cyclotrimerization of benzoCOTynes to form tri(benzo[8]annulenes) was developed. Three distinct isomers were isolated and structurally characterized by single‐crystal X‐ray diffraction. Ligand modulation proved crucial for enhancing regioselectivity: P(4‐OMePh), and (S)‐tBu‐Phox promoted the formation of the symmetric isomers.
Jesús Bello‐García   +2 more
wiley   +1 more source

Synthesis and Evaluation of Aromatic Sulfonamide and Disulfonamide Derivatives as Dengue Virus NS3–NS5 Interaction Inhibitors

open access: yesChemMedChem, Volume 21, Issue 11, 15 June 2026.
A synthetic methodology for the preparation of asymmetric benzene‐1,4‐disulfonamides was developed and applied to generate potential anti‐dengue virus (DENV) compounds. Guided by computer‐assisted structural rationalization, we designed synthetically more accessible analogs with reduced toxicity that interact with the DENV NS5 domain, thereby ...
Jakub Janáč   +8 more
wiley   +1 more source

Optimisation of a Novel Class of DNA Gyrase Inhibitors to Improve Antibacterial Activity

open access: yesChemMedChem, Volume 21, Issue 11, 15 June 2026.
This article describes efforts to increase the antibacterial activity of a recently reported class of novel DNA gyrase inhibitors known as the isoquinoline sulphonamides by improving their uptake in bacterial cells. As antibiotic resistance continues to rise, the need for new antibacterials is clear.
Meg I. Ferguson   +9 more
wiley   +1 more source

Probing 3‐Amino‐2H‐Azaindazoles as Allosteric Inhibitors of the Protein Tyrosine Phosphatase SHP2

open access: yesChemMedChem, Volume 21, Issue 11, 15 June 2026.
A palladium‐catalyzed domino reaction facilitated the discovery and rapid synthesis of selective, potent 3‐amino‐2H‐azaindazole derivatives serving as allosteric inhibitors of SHP2. Structural analysis via co‐crystallography confirmed binding at the allosteric site, thereby stabilizing the autoinhibited SHP2 conformation, qualifying this scaffold as a ...
Machoud Amoussa   +20 more
wiley   +1 more source

Stereochemical Modulation of Palladacyclopentadienyl Complexes Bearing Diphosphine Ligands: A Key to Enhanced DNA Interaction and Anticancer Activity

open access: yesEuropean Journal of Inorganic Chemistry, Volume 29, Issue 16, 4 June 2026.
A modular library of structurally robust palladacyclopentadienyl Pd(II) complexes bearing achiral and chiral diphosphines was developed, revealing a strong influence of diphosphine design and ligand chirality on cytotoxicity and selectivity against ovarian cancer cells, including platinum‐resistant models.
Stefania Mautone   +7 more
wiley   +1 more source

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