Results 191 to 200 of about 101,566 (302)

Signal Amplification in the HPT Axis—Evidence for Its Existence, Location, Significance, and Molecular Mechanisms

open access: yesActa Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Thyroid hormones (THs) are under negative feedback regulation via the hypothalamic–pituitary‐thyroid (HPT) axis. How this axis operates to keep the circulating THs within a narrow physiological range is not well understood quantitatively. Led by the design principle of robust homeostatic feedback control, here we review and synthesize the ...
Li Jing, Sarahna A. Moyd, Qiang Zhang
wiley   +1 more source

Correlation of TP53 Mutations With p53 Expression and Ki‐67 Index in Pulmonary Large Cell Neuroendocrine Carcinomas

open access: yesAPMIS, Volume 134, Issue 4, April 2026.
ABSTRACT This study explores the locations and distribution of mutations in the exons of the TP53 gene in pulmonary large cell neuroendocrine carcinomas (LCNEC) and the corresponding expression of p53 as well as the Ki‐67 proliferation index. Real‐world data from routine diagnostics were collected retrospectively from 149 consecutive cases of pulmonary
Martin Stampe   +6 more
wiley   +1 more source

Cultural Beliefs and Practices of Internationally Educated Nurses in the Context of Cancer and End‐Of‐Life Care: A Hermeneutic Inquiry

open access: yesJournal of Advanced Nursing, Volume 82, Issue 4, Page 3509-3521, April 2026.
ABSTRACT Aims This study aimed to (1) gain an understanding of the experiences of IENs in providing cancer and end‐of‐life care; (2) explore their cultural beliefs and practices and analyse how their experiences, beliefs, and practices shape approaches to nursing care within this care context. Design Hermeneutic inquiry.
Jay Balante   +2 more
wiley   +1 more source

Mechanism of interaction between the transactivation domain of N-myc and the DNA-binding surface of TFIIIC5. [PDF]

open access: yesNucleic Acids Res
Leen E   +8 more
europepmc   +1 more source

Classroom‐Integrated Kettlebell Training: Effects on Motor Performance, Attention, and Health in Primary School Children

open access: yesJournal of School Health, Volume 96, Issue 4, April 2026.
ABSTRACT Background Declining physical fitness and rising obesity in children call for effective interventions. Integrating kettlebell training into the classroom may provide a practical way to overcome existing barriers. This study examined its feasibility and effectiveness on second graders' motor performance, attention, and health.
Nicole Braun   +4 more
wiley   +1 more source

Auxin‐Induced Nicotine Inhibition Is Mediated by NaARF5 Through the Suppression of NaERF1‐Like Expression and Interaction With NaERF1‐Like in Nicotiana attenuata

open access: yesPlant Biotechnology Journal, Volume 24, Issue 4, Page 2642-2656, April 2026.
ABSTRACT Nicotine is the most abundant alkaloid produced by Nicotiana species against insect herbivores. Although it has been known for decades that auxin can strongly inhibit nicotine biosynthesis, the underlying mechanisms have remained unclear.
Miyun Yang   +3 more
wiley   +1 more source

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