Results 31 to 40 of about 66,958 (269)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Design Method of Double-Boost DC/DC Converter with High Voltage Gain for Electric Vehicles
World Electric Vehicle Journal, 2020 Direct current to direct current (DC/DC) converters are required to have higher voltage gains in some applications for electric vehicles, high-voltage level charging systems and fuel cell electric vehicles. Therefore, it is greatly important to carry out
Zhengxin Liu, Jiuyu Du, Boyang Yu
doaj +1 more source
Soft-Switching Full-Bridge DC-DC Converter with Energy Recovery Capacitor Snubber
Energies, 2023 This paper describes a high-frequency soft-switching dc-dc converter with a simple energy recovery capacitor snubber on the secondary side. The presented dc-dc full-bridge converter with the energy recovery snubber removes the main drawbacks of the ...
Marek Pastor +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Power efficiency improvement of the composite resonant DC-DC converter [PDF]
, 2012 This paper deals with the power efficiency improvement of the composite resonant DC-DC converter, which is developed to be applied to the power conditioner of the photovoltaic generation system. To improve the power efficiency, following three approaches
Ishizuka, Yoichi +3 more
core +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Design of an AC/DC Converter with using Supercapacitors as Energy Storage
RMUTL Engineering Journal, 2016 This paper presents a design of a high power factor AC/DC converter with using supercapacitors as energy storage.The proposed system consists of a cuk topology based AC/DC power converter and a bidirectional DC/DC converter which is connected between the
พิสิทธิ วิสุทธิเมธีกร +1 more
doaj
Design and Implementation of Series Resonant DC-DC Converter
Jurnal Nasional Teknik Elektro, 2020 The resonant DC-DC converter is known as advantageous over conventional DC-DC converter in terms of efficiency. This is primarily because the resonant converter operates at soft switching mode.
Firmansyah Nur Budiman, Arridha Amrad
doaj +1 more source