Results 41 to 50 of about 115,840 (262)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Projecting GaN HEMTs lifetimes under typical stresses commonly observed in DC-DC converters

Power Electronic Devices and Components, 2023
DC-DC converters exist in virtually every application of modern power electronics. Due to small die size, low on-resistance, and low parasitic capacitance, GaN power devices offer superior conversion efficiency and record-setting power density.
Shengke Zhang, Siddhesh Gajare, Ricardo Garcia, Sijun Huang, Angel Espinoza, Andrea Gorgerino, Ruizhe Zhang, Alejandro Pozo, Robert Strittmatter, Alex Lidow   +9 more
doaj   +1 more source

Per-Core DVFS with Switched-Capacitor Converters for Energy Efficiency in Manycore Processors [PDF]

, 2015
Integrating multiple power converters on-chip improves energy efficiency of manycore architectures. Switched-capacitor (SC) dc-dc converters are compatible with conventional CMOS processes, but traditional implementations suffer from limited conversion ...
Alon, E, Asanović, K, Bailey, S, Blagojević, M, Jevtić, R, Le, HP, Nikolić, B   +6 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Analysis and Optimization of DC-DC Converters Through Sensitivity to Parametric Variations

Technologies
The optimization of DC-DC converters is crucial for enhancing their performance and efficiency in various applications. This study focuses on the sensitivity analysis of DC-DC converters to parametric variations, which plays a key role in designing ...
Nikolay Hinov, Plamen Stanchev, Gergana Vacheva   +2 more
doaj   +1 more source

Hybrid and modular multilevel converter designs for isolated HVDC–DC converters [PDF]

, 2018
Efficient medium and high-voltage dc-dc conversion is critical for future dc grids. This paper proposes a hybrid multilevel dc-ac converter structure that is used as the kernel of dc-dc conversion systems.
Adam, G.P., Ahmed, Shehab, Gowaid, I.A., Massoud, Ahmed M., Williams, B.M.   +4 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Protection strategy for multi-terminal DC networks with fault current blocking capability of converters [PDF]

, 2017
High voltage dc networks are a promising technology to flexibly transmit power over long distances. However, dc grid protection is still a major challenge. DC fault clearance can be mainly achieved with three devices. These are ac circuit breakers (ACCBs)
Adamczyk, A., Barker, C., Dantas, R., Liang, Jun, Ugalde Loo, Carlos Ernesto, Whitehouse, R.   +5 more
core   +1 more source