Results 41 to 50 of about 744,488 (333)
Analysis and Optimization of DC-DC Converters Through Sensitivity to Parametric Variations
TechnologiesThe optimization of DC-DC converters is crucial for enhancing their performance and efficiency in various applications. This study focuses on the sensitivity analysis of DC-DC converters to parametric variations, which plays a key role in designing ...
Nikolay Hinov +2 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Efficient Voltage Regulation with Modified Hybrid SEPIC DC-DC-Converter
MATEC Web of Conferences, 2018 Switch mode dc-dc converters are attractive for their small size, ease of control and efficient power conversion. Output voltage is regulated by duty cycle control of semiconductor switch of switch mode dc-dc converters.
Ali Azam Khan Md. +1 more
doaj +1 more source
Ain Shams Engineering Journal, 2023 In this paper, the DC fast charger module with its circuit topologies is studied detailed. The electric vehicle batteries are charged via DC fast chargers for quick charging.
Yusuf Yasa
doaj +1 more source
Portable Low‐Field Magnetic Resonance Imaging in People With Human Immunodeficiency Virus
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The aging population of people with HIV (PWH) raises heightened concerns regarding accelerated aging and dementia. Portable, low‐field MRI (LF‐MRI) is an innovative technology that could enhance access and facilitate routine monitoring of PWH.
Annabel Sorby‐Adams +14 more
wiley +1 more source
Modified Droop Method Based on Master Current Control for Parallel-Connected DC-DC Boost Converters
Journal of Electrical and Computer Engineering, 2018 Load current sharing between parallel-connected DC-DC boost converters is very important for system reliability. This paper proposes a modified droop method based on master current control for parallel-connected DC-DC boost converters. The modified droop
Muamer M. Shebani +2 more
doaj +1 more source
Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source