Results 41 to 50 of about 8,400 (267)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

DC Fault Analysis of Modular DC/DC Converter Employing a New Submodule With Damping-Resistor

IEEE Access, 2018
DC transformer is the key equipment to interconnect the high voltage dc systems with different voltage levels and build dc grid. Compared with the dc/ac/dc converter based on modular multilevel converter, the non-isolated modular dc/dc converter (MDCC ...
Hongcheng You, Xu Cai, Liangzhong Yao, Yuanzhi Cao, Zhibing Wang   +4 more
doaj   +1 more source

Short-Circuit Fault Current Calculation Method for the Multi-Terminal DC Grid Considering the DC Circuit Breaker

Energies, 2020
The analysis and calculation of the short-circuit fault current in the DC grid is of great significance to the design and configuration of the converter station and DC circuit breaker parameters.
Haipeng Jia, Jingyuan Yin, Tongzhen Wei, Qunhai Huo, Jinke Li, Lixin Wu   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Study on Fault Current Characteristics and Current Limiting Method of Plug-In Devices in VSC-DC Distribution System

Energies, 2019
The DC (Direct Current) distribution system based on the voltage source converter (VSC-DC) has become a research hotspot due to its various advantages.
Yuqun Gao, Yongxia Han, Jinghan Zhang, Fanglei Xiao, Yuming Zhao, Licheng Li   +5 more
doaj   +1 more source

Fault equivalent model for non-blocking DC fault ride-through of hybrid MMC

电力工程技术, 2023
Compared with full-bridge modular multilevel converter (MMC), the hybrid MMC composed of half bridge sub-module and full bridge sub-module has the low cost and high DC fault ride-through capability.
WANG Zeqing, XIA Chengjun, LAI Shengjie, JI Huancong, ZHOU Yuebin, CAI Haiqing   +5 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Calculation Method for Commutation Failure Fault Level in LCC-HVDC System Under Single-Line-to-Ground Faults Considering DC Current Variation

Journal of Modern Power Systems and Clean Energy, 2023
Earlier studies have reported some calculation methods for commutation failure fault level (CFFL) in line-commutated-converter based high-voltage direct current (LCC-HVDC) system under single-line-to-ground (SLG) faults.
Renlong Zhu, Xiaoping Zhou, Hanhang Yin, Lerong Hong, An Luo, Yandong Chen, Hanting Peng   +6 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source