Results 1 to 10 of about 45,856 (116)

Melanin Synthesis Pathway Interruption: CRISPR/Cas9-mediated Knockout of dopa decarboxylase (DDC) in Harmonia axyridis (Coleoptera: Coccinellidae)

open access: yesJournal of Insect Science, 2022
CRISPR/Cas9 technology is a very powerful genome editing tool and has been used in many insect species for functional genomics studies through targeted gene mutagenesis.
Meng-meng Wu   +6 more
semanticscholar   +1 more source

Prodromal Parkinson's disease and the catecholaldehyde hypothesis: Insight from olfactory bulb organotypic cultures

open access: yesThe FASEB Journal, Volume 37, Issue 12, December 2023., 2023
Olfactory dysfunction is one of the most prevalent symptoms of Parkinson's disease preceding clinical onset by up to a decade. However, PD models focus mainly on motor symptoms and nigrostriatal degeneration. Here, we characterize cultured olfactory bulb organotypic slices and cells and explore the effect of DOPAL, a metabolite of dopamine.
Enrico Bagnoli   +6 more
wiley   +1 more source

Mixed silage with Chinese cabbage waste enhances antioxidant ability by increasing ascorbate and aldarate metabolism through rumen Prevotellaceae UCG-004 in Hu sheep

open access: yesFrontiers in Microbiology, 2022
Silage is rich in nutrients, which can make up for the lack of seasonal roughage, and has a certain promotion effect on the intensive feeding of ruminants.
Chuang Li   +11 more
semanticscholar   +1 more source

Guidelines for mouse and human DC generation

open access: yesEuropean Journal of Immunology, Volume 53, Issue 11, November 2023., 2023
The article on DC generation is part of the DC Guidelines article collection providing methods for the isolation of mouse and human cellular sources that can be cultured with different growth factors to generate the known subsets of DC. Abstract This article is part of the Dendritic Cell Guidelines article series, which provides a collection of state ...
Manfred B. Lutz   +25 more
wiley   +1 more source

Sexually dimorphic oxytocin receptor‐expressing (OXTR) neurons in the anteroventral periventricular nucleus (AVPV) in the postpartum female mouse are involved in maternal behavior

open access: yesJournal of Neuroendocrinology, Volume 35, Issue 10, October 2023., 2023
The purpose of the present study was to understand the function of sexually dimorphic OXTR neurons. The study revealed that the activity of the sexually dimorphic OXTR neurons is necessary for maternal behavior in female mice. Abstract Maternal care is crucial for the survival and development of offspring.
Kaustubh Sharma   +5 more
wiley   +1 more source

Phase 1 TRANSCEND CLL 004 study of lisocabtagene maraleucel in patients with relapsed/refractory CLL or SLL

open access: yesBlood, 2021
Bruton tyrosine kinase inhibitors (BTKi) and venetoclax are currently used to treat newly diagnosed and relapsed/refractory chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). However, most patients eventually develop resistance to these
T. Siddiqi   +12 more
semanticscholar   +1 more source

Exploring causal mechanisms and quantifying direct and indirect effects using a joint modeling approach for recurrent and terminal events

open access: yesStatistics in Medicine, Volume 42, Issue 22, Page 4028-4042, 30 September 2023., 2023
Abstract Recurrent events are commonly encountered in biomedical studies. In many situations, there exist terminal events, such as death, which are potentially related to the recurrent events. Joint models of recurrent and terminal events have been proposed to address the correlation between recurrent events and terminal events.
Fang Niu, Cheng Zheng, Lei Liu
wiley   +1 more source

Variability in nutrient composition of the edible long‐horned grasshopper (Ruspolia differens) in Uganda and its potential in alleviating food insecurity

open access: yesFood Science &Nutrition, Volume 11, Issue 6, Page 3558-3574, June 2023., 2023
Long‐horned grasshoppers are consumed in over 21 African countries. Crude protein (28%–45%), crude fat (41%–54%), and energy (582–644 Kj/100 g) of grasshoppers are comparable to that of plant and animal origins. Grasshopper meal could be considered as functional food ingredients capable of supplying adequate essential macro‐ and micronutrients ...
Margaret Kababu   +4 more
wiley   +1 more source

Preclinical In Vitro Studies with 3D Spheroids to Evaluate Cu(DDC)2 Containing Liposomes for the Treatment of Neuroblastoma

open access: yesPharmaceutics, 2021
Preclinical in vitro studies of drug candidates for anticancer therapy are generally conducted on well-established 2D cell models. Unfortunately, these models are unable to mimic the properties of in vivo tumors.
F. Hartwig, Monika Köll-Weber, R. Süss
semanticscholar   +1 more source

Monoclonal antibodies for the treatment of squamous cell carcinoma: A literature review

open access: yesCancer Reports, Volume 6, Issue 5, May 2023., 2023
Abstract Background Squamous cell carcinoma (SCC) is a relatively common and heterogenous malignancy of different organs, such as the skin, esophagus, and lungs. Although most cases experience good survival with surgical methods, management of advanced types of the disease remains challenging.
Amirhossein Tamimi   +8 more
wiley   +1 more source

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