Results 31 to 40 of about 45,856 (116)

Analysis of Expression and Functional Activity of Aromatic L-Amino Acid Decarboxylase (DDC) and Serotonin Transporter (SERT) as Potential Sources of Serotonin in Mouse Ovary

International Journal of Molecular Sciences, 2019
The origin of serotonin in the ovary is the key question for understanding mechanisms of serotonergic regulation of reproductive function. We performed a study of the expression and functional activity of the serotonin transporter (SERT) and the enzyme ...
D. A. Nikishin, N. M. Alyoshina, M. Semenova, Y. B. Shmukler   +3 more
semanticscholar   +1 more source

The Hamburg/ESO R-process Enhanced Star survey (HERES) - XI. The highly r-process-enhanced star CS 29497-004 [PDF]

, 2016
We report an abundance analysis for the highly r -process-enhanced ( r -II) star CS 29497-004, a very metal-poor giant with solar system T eff = 5013 K and [Fe/H] = −2.85, whose nature was initially discovered in the course of the HERES project.
V. Hill, N. Christlieb, T. Beers, P. Barklem, K. Kratz, K. Kratz, B. Nordström, B. Nordström, B. Pfeiffer, K. Farouqi, K. Farouqi   +10 more
semanticscholar   +1 more source

Pivotal roles of Kupffer cells in the progression and regression of DDC-induced chronic cholangiopathy

Scientific Reports, 2018
Kupffer cells (KCs) are key players in maintaining tissue homeostasis and are involved in various liver diseases. However, the roles of KCs in the pathogenesis of cholangiopathy are largely unknown.
Leila Jemail, Masashi Miyao, H. Kotani, C. Kawai, Hirozo Minami, H. Abiru, Keiji Tamaki   +6 more
semanticscholar   +1 more source

Protective effect of green perilla-derived chalcone derivative DDC on amyloid β protein-induced neurotoxicity in primary cortical neurons.

Biological and Pharmaceutical Bulletin, 2019
Amyloid β protein (Aβ) causes neurotoxicity and cognitive impairment in Alzheimer's disease (AD). Oxidative stress is closely related to the pathogenesis of AD.
M. Iwasaki, Naotaka Izuo, Yasuhiko Izumi, Yuki Takada‐Takatori, A. Akaike, T. Kume   +5 more
semanticscholar   +1 more source

The Oral β-Lactamase SYN-004 (Ribaxamase) Degrades Ceftriaxone Excreted into the Intestine in Phase 2a Clinical Studies

Antimicrobial Agents and Chemotherapy, 2017
SYN-004 (ribaxamase) is a β-lactamase designed to be orally administered concurrently with intravenous β-lactam antibiotics, including most penicillins and cephalosporins.
J. Kokai-Kun, Tracey E. Roberts, Olivia Coughlin, É. Sicard, Marianne Rufiange, R. Fedorak, C. Carter, M. Adams, J. Longstreth, Heidi Whalen, Joseph A. Sliman   +10 more
semanticscholar   +1 more source

Observational study of lenalidomide in patients with mantle cell lymphoma who relapsed/progressed after or were refractory/intolerant to ibrutinib (MCL-004)

Journal of Hematology & Oncology, 2017
BackgroundThe observational MCL-004 study evaluated outcomes in patients with relapsed/refractory mantle cell lymphoma who received lenalidomide-based therapy after ibrutinib failure or intolerance.MethodsThe primary endpoint was investigator-assessed ...
Michael L. Wang, S. Schuster, T. Phillips, I. Lossos, A. Goy, S. Rule, M. Hamadani, N. Ghosh, C. Reeder, Evelyn Barnett, M. Bravo, P. Martin   +11 more
semanticscholar   +1 more source

Immunogenicity of AGS-004 Dendritic Cell Therapy in Patients Treated During Acute HIV Infection.

AIDS Research and Human Retroviruses, 2017
AGS-004 consists of matured autologous dendritic cells co-electroporated with in vitro transcribed RNA encoding autologous HIV antigens. In an open-label, single arm sub-study of AGS-004-003, AGS-004 was administered monthly to suppressed participants ...
C. Gay, M. Debenedette, I. Tcherepanova, A. Gamble, W. Lewis, A. Cope, J. Kuruc, K. McGee, Mary F. Kearney, J. Coffin, N. Archin, C. Hicks, J. Eron, C. Nicolette, D. Margolis   +14 more
semanticscholar   +1 more source

A phase 1 and randomized controlled phase 2 trial of the safety and efficacy of the combination of gemcitabine and docetaxel with ontuxizumab (MORAb‐004) in metastatic soft‐tissue sarcomas

Cancer, 2019
Ontuxizumab, a humanized monoclonal antibody, targets endosialin (tumor endothelial marker 1 [TEM‐1] or CD248), which is expressed on sarcoma cells and is believed to be involved in tumor angiogenesis.
Robin L. Jones, S. Chawla, S. Attia, P. Schöffski, H. Gelderblom, B. Chmielowski, A. Le Cesne, B. V. Van Tine, J. Trent, Shreyaskumar R Patel, A. Wagner, R. Chugh, J. Heyburn, S. Weil, Wenquan Wang, K. Viele, R. Maki   +16 more
semanticscholar   +1 more source

MPX-004 and MPX-007: New Pharmacological Tools to Study the Physiology of NMDA Receptors Containing the GluN2A Subunit

PLoS ONE, 2016
GluN2A is the most abundant of the GluN2 NMDA receptor subunits in the mammalian CNS. Physiological and genetic evidence implicate GluN2A-containing receptors in susceptibility to autism, schizophrenia, childhood epilepsy and neurodevelopmental disorders
R. Volkmann, C. Fanger, David R Anderson, V. Sirivolu, K. Paschetto, Earl Gordon, C. Virginio, Mélanie Gleyzes, B. Buisson, E. Steidl, Susanna B. Mierau, M. Fagiolini, F. Menniti   +12 more
semanticscholar   +1 more source

USP38, FREM3, SDC1, DDC, and LOC727982 Gene Polymorphisms and Differential Susceptibility to Severe Malaria in Tanzania

Journal of Infectious Diseases, 2015
Populations exposed to Plasmodium falciparum infection develop genetic mechanisms of protection against severe malarial disease. Despite decades of genetic epidemiological research, the sickle cell trait (HbAS) sickle cell polymorphism, ABO blood group ...
A. Manjurano, N. Sepúlveda, Behzad Nadjm, G. Mtove, Hannah Wangai, C. Maxwell, R. Olomi, Hugh Reyburn, C. Drakeley, E. Riley, T. Clark   +10 more
semanticscholar   +1 more source