Results 11 to 20 of about 27,252 (113)

Nivolumab and Relatlimab in Patients With Advanced Melanoma That Had Progressed on Anti–Programmed Death-1/Programmed Death Ligand 1 Therapy: Results From the Phase I/IIa RELATIVITY-020 Trial

Journal of Clinical Oncology, 2023
PURPOSE Nivolumab and relatlimab activity in advanced melanoma with prior progression on anti–programmed death-1/programmed death ligand 1 (PD-(L)1)-containing regimens is under investigation.
P. Ascierto, E. Lipson, R. Dummer, J. Larkin, G. Long, R. Sanborn, V. Chiarion-Sileni, B. Dréno, S. Dalle, D. Schadendorf, M. Callahan, M. Nyakas, V. Atkinson, C. Gomez-Roca, N. Yamazaki, H. Tawbi, Naomey Sarkis, D. Warad, S. Dolfi, Priyam Mitra, S. Suryawanshi, J. Grob   +21 more
semanticscholar   +1 more source

Acutely Inhibiting AQP4 With TGN-020 Improves Functional Outcome by Attenuating Edema and Peri-Infarct Astrogliosis After Cerebral Ischemia

Frontiers in Immunology, 2022
Background Ischemic stroke is one of the leading causes of human death and disability. Brain edema and peri-infarct astrocyte reactivity are crucial pathological changes, both involving aquaporin-4 (AQP4).
Cheng-Yun Sun, Luyi Lin, L. Yin, X. Hao, J. Tian, Xiao-xue Zhang, Yan Ren, C. Li, Yanmei Yang   +8 more
semanticscholar   +1 more source

Guidelines for mouse and human DC generation

European Journal of Immunology, Volume 53, Issue 11, November 2023., 2023
The article on DC generation is part of the DC Guidelines article collection providing methods for the isolation of mouse and human cellular sources that can be cultured with different growth factors to generate the known subsets of DC. Abstract This article is part of the Dendritic Cell Guidelines article series, which provides a collection of state ...
Manfred B. Lutz, Shafaqat Ali, Cindy Audiger, Stella E. Autenrieth, Luciana Berod, Venetia Bigley, Laura Cyran, Marc Dalod, Jan Dörrie, Diana Dudziak, Georgina Flórez‐Grau, Lucila Giusiano, Gloria J. Godoy, Marion Heuer, Anne B. Krug, Christian H. K. Lehmann, Christian T. Mayer, Shalin H. Naik, Stefanie Scheu, Gerty Schreibelt, Elodie Segura, Kristin Seré, Tim Sparwasser, Jurjen Tel, Huaming Xu, Martin Zenke   +25 more
wiley   +1 more source

Melanin Synthesis Pathway Interruption: CRISPR/Cas9-mediated Knockout of dopa decarboxylase (DDC) in Harmonia axyridis (Coleoptera: Coccinellidae)

Journal of Insect Science, 2022
CRISPR/Cas9 technology is a very powerful genome editing tool and has been used in many insect species for functional genomics studies through targeted gene mutagenesis.
Meng-meng Wu, Xu Chen, Qingbiao Xu, L. Zang, Su Wang, Ming Li, D. Xiao   +6 more
semanticscholar   +1 more source

Monoclonal antibodies for the treatment of squamous cell carcinoma: A literature review

Cancer Reports, Volume 6, Issue 5, May 2023., 2023
Abstract Background Squamous cell carcinoma (SCC) is a relatively common and heterogenous malignancy of different organs, such as the skin, esophagus, and lungs. Although most cases experience good survival with surgical methods, management of advanced types of the disease remains challenging.
Amirhossein Tamimi, Atena Tamimi, Fatemeh Sorkheh, Saba Mardekatani Asl, Arezoo Ghafari, Arian Ghannadi Karimi, Gisou Erabi, Hossein Pourmontaseri, Niloofar Deravi   +8 more
wiley   +1 more source

Preclinical In Vitro Studies with 3D Spheroids to Evaluate Cu(DDC)2 Containing Liposomes for the Treatment of Neuroblastoma

Pharmaceutics, 2021
Preclinical in vitro studies of drug candidates for anticancer therapy are generally conducted on well-established 2D cell models. Unfortunately, these models are unable to mimic the properties of in vivo tumors.
F. Hartwig, Monika Köll-Weber, R. Süss
semanticscholar   +1 more source

Commodity risk assessment of Prunus persica and P. dulcis plants from Türkiye

EFSA Journal, Volume 21, Issue 1, January 2023., 2023
Abstract The European Commission requested the EFSA Panel on Plant Health to prepare and deliver risk assessments for commodities listed in Commission Implementing Regulation (EU) 2018/2019 as ‘High risk plants, plant products and other objects’. This Scientific Opinion covers plant health risks posed by plants of Prunus persica and P.
EFSA Panel on Plant Health (PLH), Claude Bragard, Paula Baptista, Elisavet Chatzivassiliou, Paolo Gonthier, Josep Anton Jaques Miret, Annemarie Fejer Justesen, Alan MacLeod, Christer Sven Magnusson, Panagiotis Milonas, Juan A Navas‐Cortes, Stephen Parnell, Roel Potting, Philippe Lucien Reignault, Emilio Stefani, Hans‐Hermann Thulke, Wopke Van der Werf, Antonio Vicent Civera, Lucia Zappalà, Andrea Lucchi, Pedro Gómez, Gregor Urek, Umberto Bernardo, Giovanni Bubici, Anna Vittoria Carluccio, Michela Chiumenti, Francesco Di Serio, Elena Fanelli, Agata Kaczmarek, Cristina Marzachì, Olaf Mosbach‐Schulz, Jonathan Yuen   +31 more
wiley   +1 more source

Stability Analysis of Cyber Physical Microgrid with Dynamic Demand Control considering Time Delays

International Transactions on Electrical Energy Systems, Volume 2022, Issue 1, 2022., 2022
Time delays are enforced into the LFC system of microgrid (MG) while transmitting the control signals from the central controller and also aggregating the controllable loads of Demand Side Response (DSR). Due to these delays, the system dynamic performance gets affected leading to system instability. The time delays may be fixed or time varying.
J. Sumithra, N. M. Jothi Swaroopan, Gulshan Sharma   +2 more
wiley   +1 more source

Investigating the AC079305/DUSP1 Axis as Oxidative Stress‐Related Signatures and Immune Infiltration Characteristics in Ischemic Stroke

Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022
Background. Oxidative stress (OS) and immune inflammation play complex intersections in the pathophysiology of ischemic stroke (IS). However, a competing endogenous RNA‐ (ceRNA‐) based mechanism linked to the intersections in IS has not been explored. We aimed to identify potential OS‐related signatures and analyze immune infiltration characteristics ...
Jiaxin Fan, Shuai Cao, Mengying Chen, Qingling Yao, Xiaodong Zhang, Shuang Du, Huiyang Qu, Yuxuan Cheng, Shuyin Ma, Meijuan Zhang, Yizhou Huang, Nan Zhang, Kaili Shi, Shuqin Zhan, Junlei Chang   +14 more
wiley   +1 more source

Burden of arrhythmia in hospitalized HIV patients

Clinical Cardiology, Volume 44, Issue 1, Page 66-77, January 2021., 2021
Abstract Background The improved life expectancy observed in patients living with human immunodeficiency virus (HIV) infection has made age‐related cardiovascular complications, including arrhythmias, a growing health concern. Hypothesis We describe the temporal trends in frequency of various arrhythmias and assess impact of arrhythmias on hospitalized
Anas A. Abudan, Vaibhav R. Vaidya, Byomesh Tripathi, Peter A. Noseworthy, Daniel C. DeSimone, Alexander Egbe, Shilpkumar Arora, Haarini Sridhar, Christopher V. DeSimone, Siva Mulpuru, Abhishek J. Deshmukh   +10 more
wiley   +1 more source