Results 31 to 40 of about 27,252 (113)

Nrf2 Ameliorates DDC-Induced Sclerosing Cholangitis and Biliary Fibrosis and Improves the Regenerative Capacity of the Liver.

Toxicological Sciences, 2019
The Nrf2 pathway protects against oxidative stress and induces regeneration of various tissues. Here, we investigated whether Nrf2 protects from sclerosing cholangitis and biliary fibrosis and simultaneously induces liver regeneration.
A. Fragoulis, J. Schenkel, M. Herzog, Tim Schellenberg, H. Jahr, T. Pufe, C. Trautwein, T. Kensler, K. Streetz, C. Wruck   +9 more
semanticscholar   +1 more source

Comprehensive proteomics of CSF, plasma, and urine identify DDC and other biomarkers of early Parkinson’s disease

Acta Neuropathologica
Parkinson’s disease (PD) starts at the molecular and cellular level long before motor symptoms appear, yet there are no early-stage molecular biomarkers for diagnosis, prognosis prediction, or monitoring therapeutic response.
J. Rutledge, B. Lehallier, Pardis Zarifkar, P. M. Losada, M. Shahid-Besanti, D. Western, P. Gorijala, S. Ryman, M. Yutsis, Gayle K. Deutsch, E. Mormino, A. Trelle, Anthony D. Wagner, G. Kerchner, Lu Tian, C. Cruchaga, Victor W. Henderson, T. Montine, P. Borghammer, Tony Wyss-Coray, K. Poston   +20 more
semanticscholar   +1 more source

Analysis of Expression and Functional Activity of Aromatic L-Amino Acid Decarboxylase (DDC) and Serotonin Transporter (SERT) as Potential Sources of Serotonin in Mouse Ovary

International Journal of Molecular Sciences, 2019
The origin of serotonin in the ovary is the key question for understanding mechanisms of serotonergic regulation of reproductive function. We performed a study of the expression and functional activity of the serotonin transporter (SERT) and the enzyme ...
D. A. Nikishin, N. M. Alyoshina, M. Semenova, Y. B. Shmukler   +3 more
semanticscholar   +1 more source

Evaluation of Strength and Irradiated Movement Pattern Resulting from Trunk Motions of the Proprioceptive Neuromuscular Facilitation

Rehabilitation Research and Practice, Volume 2012, Issue 1, 2012., 2012
Introduction. The proprioceptive neuromuscular facilitation (PNF) is a physiotherapeutic concept based on muscle and joint proprioceptive stimulation. Among its principles, the irradiation is the reaction of the distinct regional muscle contractions to the position of the application of the motions. Objective.
Luciana Bahia Gontijo, Polianna Delfino Pereira, Camila Danielle Cunha Neves, Ana Paula Santos, Dionis de Castro Dutra Machado, Victor Hugo do Vale Bastos, Luc Vanhees   +6 more
wiley   +1 more source

Strong Trinucleotide Circular Codes

International Journal of Combinatorics, Volume 2011, Issue 1, 2011., 2011
Recently, we identified a hierarchy relation between trinucleotide comma‐free codes and trinucleotide circular codes (see our previous works). Here, we extend our hierarchy with two new classes of codes, called DLD and LDL codes, which are stronger than the comma‐free codes.
Christian J. Michel, Giuseppe Pirillo, Toufik Mansour   +2 more
wiley   +1 more source

Dynamic Field Theory of Executive Function: Identifying Early Neurocognitive Markers

Monographs of the Society for Research in Child Development, Volume 89, Issue 3, Page 7-109, December 2024.
Abstract In this Monograph, we explored neurocognitive predictors of executive function (EF) development in a cohort of children followed longitudinally from 30 to 54 months of age. We tested predictions of a dynamic field model that explains development in a benchmark measure of EF development, the dimensional change card sort (DCCS) task.
Alexis McCraw, Jacqueline Sullivan, Kara Lowery, Rachel Eddings, Hollis R. Heim, Aaron T. Buss   +5 more
wiley   +1 more source

Current Use of Nucleoside Analogues in the Treatment of HIV Infection

Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 5, Issue E, Page 21E-26E, 1994., 1994
Nucleoside analogues continue to play a central role in the treatment of HIV infection. The recently published Concorde I.rial has been misinterpreted as demonstrating a Jack of efficacy of zidovudine in the treatment of HIV disease. This is clearly not the case because zidovudine was prescribed to patients in both arms of the study. The Concorde study
Julio SG Montaner, Carlos Zala, Leila Spour   +2 more
wiley   +1 more source

NT-020 treatment reduces inflammation and augments Nrf-2 and Wnt signaling in aged rats

Journal of Neuroinflammation, 2015
BackgroundAging is associated with a decline in stem cell proliferation that is thought to be a result of dysregulated signaling in the neurogenic niche. This results in a diminished and less efficient pool of progenitors.
Antwoine Flowers, Jea-Young Lee, Sandra A. Acosta, C. Hudson, B. Small, C. Sanberg, P. Bickford   +6 more
semanticscholar   +2 more sources

Pivotal roles of Kupffer cells in the progression and regression of DDC-induced chronic cholangiopathy

Scientific Reports, 2018
Kupffer cells (KCs) are key players in maintaining tissue homeostasis and are involved in various liver diseases. However, the roles of KCs in the pathogenesis of cholangiopathy are largely unknown.
Leila Jemail, Masashi Miyao, H. Kotani, C. Kawai, Hirozo Minami, H. Abiru, Keiji Tamaki   +6 more
semanticscholar   +1 more source

Protective effect of green perilla-derived chalcone derivative DDC on amyloid β protein-induced neurotoxicity in primary cortical neurons.

Biological and Pharmaceutical Bulletin, 2019
Amyloid β protein (Aβ) causes neurotoxicity and cognitive impairment in Alzheimer's disease (AD). Oxidative stress is closely related to the pathogenesis of AD.
M. Iwasaki, Naotaka Izuo, Yasuhiko Izumi, Yuki Takada‐Takatori, A. Akaike, T. Kume   +5 more
semanticscholar   +1 more source