Results 31 to 40 of about 10,182 (76)

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains

Brain Pathology, EarlyView.
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña, Enric Vidal, Natalia Fernández‐Borges, Jorge M. Charco, Carlos M. Díaz‐Domínguez, Cristina Sampedro‐Torres‐Quevedo, Josu Galarza‐Ahumada, Eva Fernández‐Muñoz, Maitena San‐Juan‐Ansoleaga, Miguel Ángel Pérez‐Castro, Nuno Gonçalves‐Anjo, Patricia Piñeiro, Samanta Giler, Nora González‐Martín, Nuria L. Lorenzo, Africa Manero‐Azua, Guiomar Perez de Nanclares, Mariví Geijo, Manuel A. Sánchez‐Martín, Jesús R. Requena, Joaquín Castilla   +20 more
wiley   +1 more source

SOX30 Governs Synaptonemal Complex Assembly and Homologous Recombination in Male Meiosis

Cell Proliferation, EarlyView.
The transcription factor SOX30 directly binds promoter regions of SYCE1 and SYCE2 to mediate their transcriptional activation, thereby enabling proper assembly of central elements within the synaptonemal complex. Structural destabilisation of the synaptonemal complex in Sox30 KK spermatocytes triggers synaptic discontinuity, impairs homologous ...
Kangle Liu, Wenfeng Zhang, Xiao Jiang, Jianping Chen, Lei Zhu, Zhonghao Zhang, Jing Gu, Lulu Guo, Lin Ao, Qing Chen, Lei Sun, Yuhan Hu, Xin Wang, Yaxin Liu, Jia Cao, Fei Han, Jinyi Liu   +16 more
wiley   +1 more source

Irradiated Liver Cancer Cell Vaccine Transfected With GM‐CSF Induces Specific and Long‐Lasting Anti‐tumour Immunity Through the Synergistic Effect of Oxidised mtDNA and GM‐CSF

Cell Proliferation, EarlyView.
Song et al. developed an mGM‐CSF‐loaded, liver cancer cell‐based vaccine that potently activated dendritic cells and elicited tumour‐specific T cell responses. Mechanistically, radiation‐induced oxidative damage to mitochondrial DNA in cancer cells triggers the cGAS‐STING pathway in DCs, which synergizes with mGM‐CSF‐driven JAK2‐STAT3 signalling to ...
Zhiruo Song, Yujie Jiang, Yu Zhang, Danyi Ao, Chunjun Ye, Xiya Huang, Yingqiong Zhou, Hanle Yang, Ruolan Xia, Jiayuan Ai, Dandan Wan, Aiping Tong, Yuquan Wei, Xuemei He, Aqu Alu, Xiawei Wei   +15 more
wiley   +1 more source

Placental‐Derived Connective Tissue Matrix Mediates Murine Recurrent Laryngeal Nerve Regeneration

The Laryngoscope, Volume 136, Issue 5, Page 2220-2231, May 2026.
Placentally derived connective tissue matrix (pd‐CTM) innately contains various neurotrophic, angiogenic, anti‐inflammatory, and tissue remodeling cytokines. In this mouse model of unilateral vocal fold paralysis, we investigate its effects on recurrent laryngeal nerve (RLN) regeneration and reinnervation of the right thyroarytenoid (TA) muscle after ...
Sunjay Anekal, Ananya Tadikonda, Gabriel Sobczak, Lena W. Chen, Aditya Bhatt, Troy Wesson, Patrick R. Finnegan, Stacey Halum   +7 more
wiley   +1 more source

Mechanical Force Promotes Mitochondrial Transfer From Macrophages to BMSCs to Enhance Bone Formation

Cell Proliferation, Volume 59, Issue 5, May 2026.
Mechanical tension activates Drp1‐mediated mitochondrial fission in macrophages, facilitating the release of Mito‐EVs that are subsequently transferred to BMSCs. Additionally, the CD200R‐CD200 interaction enhances the uptake of these mechanically stimulated macrophage‐derived Mito‐EVs by BMSCs, ultimately promoting osteogenic differentiation.
Yingyi Li, Ziwei Yan, Yueming Dai, Hanjia Cai, Yue Chen, Yuyi Chen, Ruofan Jin, Wen Sun, Hua Wang   +8 more
wiley   +1 more source

Fit for purpose? Analysis of the relationship between skull, beak shape and feeding ecology in Psittaciformes

Journal of Anatomy, Volume 248, Issue 5, Page 873-887, May 2026.
Psittaciformes exhibit high levels of morphological diversity, particularly in skull and beak structure, previously linked to diet and body size. Although there were some levels of significance between diet and beak shape, body mass was a much stronger co‐variate. Diet is not determining beak shape within the clade.
Shannon L. Harrison, Gregory P. Sutton, D. Charles Deeming   +2 more
wiley   +1 more source

An immunobiliary single-cell atlas resolves crosstalk between type 2 conventional dendritic cells and γδ T cells in cholangitis. [PDF]

Nat Commun
Thomann S, Hemmer H, Agrawal A, Basu S, Schaf J, Vornberger N, Krammer T, Sagar, Imdahl F, Poth T, Tóth M, Zielinski CE, Poch T, Krause J, Rosenwald A, Breitkopf-Heinlein K, Rahbari N, Grün D.   +17 more
europepmc   +1 more source

A quantitative DOPA decarboxylase biomarker for diagnosis in Lewy body disorders. [PDF]

Nat Med
Bolsewig K, Bellomo G, Hok-A-Hin YS, Al Idrissi I, Vermunt L, Lleó A, Alcolea D, Sieben A, Engelborghs S, Simonsen AH, Hasselbalch SG, Bech S, Morrema THJ, Hoozemans JJM, Bol JGJM, van Alphen J, Gaetani L, Chiasserini D, Paolini Paoletti F, Parnetti L, Kang S, Lee YG, Jeon S, Lee A, Jeon S, Ye BS, Del Campo Milán M, van der Flier WM, van de Berg WDJ, Lemstra AW, Willemse EAJ, Teunissen CE.   +31 more
europepmc   +1 more source

Dietary Lauric Acid Suppresses Inflammation, Cholestasis, Hepatocyte Injury, and Senescence in 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine-induced Inflammatory Cholangiopathy. [PDF]

Cell Mol Gastroenterol Hepatol
Ghosh S, Devereaux MW, Anderson AL, Anderson CC, D'Alessandro A, Orlicky DJ, Sokol RJ.   +6 more
europepmc   +1 more source

Loss of β-catenin in cholangiocytes promotes hepatocyte reprogramming and vascular remodeling during murine cholestasis. [PDF]

Cell Commun Signal
Carson M, Fornsaglio J, Case Iv R, Aggarwal R, Meadows V, Kim CK, Molina L, Cornuet P, Liu JJ, Liu S, Nejak-Bowen K.   +10 more
europepmc   +1 more source